Method for preparing konjak glucosan ester in organic medium by biological catalyzation

A technology of konjac glucomannan and glucomannan ester, which is applied in the field of preparation of functional polymer materials, can solve the problems of by-products and difficult separation of products, complex reaction system, poor reaction selectivity, etc., and achieve high product purity, The effect of simple reaction system and easy separation

Inactive Publication Date: 2005-07-20
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional chemical methods prepare glucomannan esters, the reaction system is complex, the reaction temperature is high, the energy consumption is large, the reaction selectivity is poor, by-products are easily produced and the products are difficult to separate; and it will bring serious environmental pollution problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Put konjac glucomannan, lipase, fatty acid vinyl ester, and organic solvent into airtight containers filled with saturated saline solution to balance until the water activity is 0.23, and mix 0.50g konjac glucomannan, 2,500U lipase (from Candida antarctica), 1.0ml butyl acetate, 50.0ml isooctane (1gP=4.7) were put into a stoppered Erlenmeyer flask, sealed tightly with polytetrafluoroethylene sealing tape and placed in a 30°C, 100rpm Shake in a constant temperature shaker in a water bath. After reacting for 48 hours, the reactor was taken out, absolute ethanol was added to stop the reaction, the precipitate obtained by removing the mixed solvent by suction filtration was fully washed with absolute ethanol, and dried to constant weight. The lipase was removed through an 80-mesh sieve to obtain konjac glucomannan acetate with a degree of substitution of 0.12.

Embodiment 2

[0025] Put konjac glucomannan, lipase, fatty acid vinyl ester, and organic solvent into airtight containers filled with saturated saline solution to balance until the water activity is 0.23, and mix 0.50g konjac glucomannan, 2,500U lipase (from Candida antarctica), 1.0ml ethyl octanoate, 50.0ml isooctane (1gP=4.7) were put into a stoppered Erlenmeyer flask in sequence, and the bottle mouth was strictly sealed with a polytetrafluoroethylene sealing tape, and placed at 30°C, 100rpm Oscillate in a constant temperature shaker in a water bath. After reacting for 48 hours, the reactor was taken out, absolute ethanol was added to stop the reaction, the precipitate obtained by removing the mixed solvent by suction filtration was fully washed with absolute ethanol, and dried to constant weight. The lipase was removed through a 80-mesh sieve to obtain konjac glucomannan octanoate with a degree of substitution of 0.16.

Embodiment 3

[0027] Put 0.50 g of konjac glucomannan with a water activity of 0.11, 1,500 U of lipase (from Rhizomucor miehei), 2.6 ml of vinyl acetate, and 16.7 ml of isooctane (1 gP = 4.7) into a stoppered Erlenmeyer flask in sequence , tightly seal the bottle mouth with polytetrafluoroethylene sealing tape, and place it in a water bath constant temperature oscillator at 30°C and 170rpm to vibrate. After reacting for 48 hours, the reactor was taken out, absolute ethanol was added to stop the reaction, the precipitate obtained by removing the mixed solvent by suction filtration was fully washed with absolute ethanol, and dried to constant weight. Remove the lipase through a 200-mesh sieve to obtain konjac glucomannan acetate with a degree of substitution of 0.25.

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Abstract

The method of biologically catalyzing in organic medium to prepare konjak glucomannan ester is to adopt organic solvent with common logarithm of distribution coefficient lg P of 1.0-4.7 as the reaction medium, C2-C18 fatty acid ester as acetyl donor and lipase to catalyze the esterification of konjak glucomannan to obtain konjak glucomannan ester. The method of the present invention has mild condition, low power consumption, environment friendship, simple reaction process, reaction controllability and selectivity, and easy separation of the product.

Description

technical field [0001] The invention relates to a preparation method of a functional polymer material, in particular to a method for biocatalytically preparing konjac glucomannan ester in an organic medium. Background technique [0002] Konjac Glucomannan (KGM for short) is a polysaccharide from the plant Konjac, and it is also a unique renewable resource in southern my country and Southeast Asian countries. KGM is a complex polysaccharide formed by combining D-glucose (G) and D-mannose (M) at a molar ratio of 1:1.6 or 1:1.69 through a β-1,4-pyranoside bond. Short-chain branched and contains a small amount of acetyl groups. KGM has high viscosity and unique rheological properties, excellent biodegradability, biocompatibility and many unique physiological and pharmacological functions, and is expected to have important clinical application value in the field of medicine and preventive medicine. At present, it has been widely used in food, chemical, textile, petroleum and co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02
Inventor 李光吉丁锐陈志刚宗敏华
Owner SOUTH CHINA UNIV OF TECH
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