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Ureter rack tube made of absorbable material

A technology of ureteral stents and absorbent materials, which can be applied to devices with tubular structures in the human body, medical science, and prostheses. It can solve problems such as low molecular weight, difficulty in developing practical products, and fast absorption, so as to reduce pain and Burden, good for imaging and development, good biocompatibility

Inactive Publication Date: 2005-09-28
CHENGDU ORGANIC CHEM CO LTD CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported in foreign literature (Laaksovirta S., Laurila M.et al.J Urol, 167: 1527, 2002) that the absorbable polyglycolide (PLGA) material is used to make the stent tube, and the shortcoming of the stent tube is that the molecular weight Low, fast absorption, about 1 week, and the material is a typical plastic body, hard, poor elasticity, so it has a stimulating effect on the tissue, it is difficult to develop a practical product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation of ε-caprolactone-DL-lactide copolymer: 50 grams each of dehydrated and purified ε-caprolactone and DL-lactide were placed in a 500ml reaction bottle, and then 0.01% The stannous octoate catalyst was reacted under vacuum conditions at 150°C for 6 hours to obtain an elastic polymer, which was dissolved in acetone and precipitated in ethanol, and the precipitate was dried in a vacuum desiccator for 48 hours to obtain Elastomer material. The molecular weight of the product is 300,000, and the ε-caprolactone unit in the ε-caprolactone-lactide copolymer accounts for 49.6% as determined by the NMR C13 spectrum. The glass transition temperature was determined to be 3°C.

[0020] The ε-caprolactone-lactide copolymer synthesized above was extruded in an extruder at a temperature of 100-135°C. The outer diameter of the formed ureteral stent was 2.8mm, the inner diameter was 1.9mm, and the appearance of the pipe was transparent.

Embodiment 2

[0021] Example 2 Put 65 grams of dehydrated and purified ε-caprolactone and 35 grams of DL-lactide into a 500ml reaction bottle, then add 0.01% stannous octoate catalyst, and react under vacuum conditions at 150°C After 7 hours, an elastic copolymer was obtained. The copolymer was dissolved in acetone, precipitated in ethanol, and the precipitate was dried in a vacuum desiccator for 48 hours to obtain an elastomer material. The molecular weight is 480,000. The glass transition temperature was determined to be -8°C.

[0022] The ε-caprolactone-DL-lactide copolymer synthesized above was extruded in an extruder at a temperature of 145°C. The outer diameter of the formed ureteral stent was 2.8 mm, the inner diameter was 1.9 mm, and the appearance of the tube was transparent.

Embodiment 3

[0023] Example 3 Preparation of ε-caprolactone-L-lactide copolymer: 65 grams of dehydrated and purified ε-caprolactone and 35 grams of L-lactide were placed in a 500ml reaction flask, and then 0.01 % stannous octoate catalyst, reacted under vacuum condition and 150 ℃ for 5 hours, obtained the multipolymer of elasticity, this multipolymer was dissolved in acetone, precipitated in ethanol, and the precipitate was dried in a vacuum drier for 48 hours. Obtain an elastomeric material. The molecular weight is 100,000. The glass transition temperature was determined to be -9°C.

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Abstract

The present invention discloses one kind of medical ureter rack tube made of absorbable material. The absorbable material is epsilon-caprolactone-lactide copolymer or the copolymer of epsilon-caprolactone and lactide and / or diglycolide of molecular weight 50-800 KD, where epsilon-caprolactone accounts for 10-80 wt% of the copolymer and the lactide is DL-lactide or L-lactide. The absorbable material for ureter rack tube has excellent biocompatibility, can degrade automatically and may be exhausted out after degrading with less pain and burden.

Description

technical field [0001] The invention relates to a ureteral stent tube in surgical operations, more specifically, the invention relates to a ureteral stent tube made of absorbable materials, which belongs to the technical field of medical biomaterials. Background technique [0002] Ureteral stents are widely used in surgical operations, and are suitable for upper urinary tract operations such as kidney stones, ureteral stones, hydronephrosis, kidney transplantation, benign tumors of the kidney and ureter, as well as treatment processes such as lithotripsy by lithotripsy and dilation of ureteral strictures It plays an important role in draining urine and preventing ureteral stricture. However, the currently used ureteral stents are mainly made of silicone, polyurethane and other raw materials that cannot be degraded or absorbed in the human body. When the stones formed in the body for a long time cannot be removed through the cavity, open surgery has t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/04A61L27/14A61L27/58A61M29/00
Inventor 熊成东孙蕊张胜蓝
Owner CHENGDU ORGANIC CHEM CO LTD CHINESE ACAD OF SCI
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