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Anticarcinogenic internal implant agent

An implant and anti-cancer drug technology, applied in the field of anti-cancer drugs, can solve the problem of local formation of effective drug concentration in difficult tumors, achieve the effect of inhibiting and destroying DNA repair function and increasing the therapeutic effect

Inactive Publication Date: 2005-10-12
SHANDONG LANJIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the excessive expansion and hyperplasia of solid tumors, the interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity are all higher than those of the surrounding normal tissues. Therefore, it is difficult for conventional chemotherapy to form an effective drug concentration in the tumor. The dose is limited by the systemic response

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Put the weighed (80 mg) pharmaceutical excipient (polylactic acid (PLA) with a molecular weight of 10,000) into the container, add a certain amount of organic solvent to dissolve and mix (subject to full dissolution), then add 10 mg of camox Ting and 10mg melphalan, re-shake and vacuum-dry to remove the organic solvent. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain an anti-cancer in vivo implant containing 10% carmustine and 10% melphalan. The above are percentages by weight.

Embodiment 2

[0089] As described in Example 1, the difference is that the anticancer active ingredients are:

[0090] a) 5-25% of astramustine, streptozocin, amustine, amustine, nimustine, bendamustine, dithiomustine, bofuramustine, Carmustine, emustine, ecomustine, dithiamustine, garmustine, formustine, estramustine, comustine, nemustine, mannomustine , lomustine, methyllomustine, semustine, ramustine, samustine, prednimustine, uramustine, taurmustine, tamustine or Spiromustine and 5-25% tumor canine, cyclophosphamide, ifosfamide, melphalan, 4H-cyclophosphamide peroxide, methoxy mustard, hexamethazine, letrozole, cantharidin, a combination of norcantharidin or azathepa; or

[0091] b) 5-25% of orestamustine, streptozocin, amustine, amustine, nimustine, bendamustine, dithiomustine, bofuramustine, Carmustine, emustine, ecomustine, dithiamustine, garmustine, formustine, estramustine, comustine, nemustine, mannomustine , lomustine, methyllomustine, semustine, ramustine, samustine, prednim...

Embodiment 3

[0095] Put the pharmaceutical excipient weighing 85 mg, polylactic acid (PLGA) with a molecular weight of 15,000 into a container, add a certain amount of organic solvent to dissolve and mix well, subject to full dissolution, then add 10 mg of nimustine and 5 mg of albino Mycin, shake again and dry in vacuo to remove organic solvents. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain an anti-cancer in vivo implant containing 10% nimustine and 5% doxorubicin. All are percentages by weight.

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PUM

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Abstract

An anticancer in vivo implant applied locally is prepared from the anticancer nitrosourea-type medicine, the anticancer synergist chosen from bichloroethanamine-type alkylating agent, anticancer antibiotic, and hormone-type anticancer medicine, and the biocompatible and biodegradable high-molecular polymer as medicinal additive.

Description

(1) Technical field [0001] The invention relates to an anticancer body implant, belonging to the technical field of anticancer drugs. (2) Background technology [0002] The treatment of solid tumors mainly includes surgery, radiotherapy and chemotherapy. Among the various chemotherapeutic drugs used, nitrosourea anticancer drugs have obvious effects and have been widely used in various malignant tumors. However, further research found that the DNA repair function in many tumor cells increased significantly after the treatment. The latter often leads to enhanced resistance of tumor cells to nitrosourea anticancer drugs, resulting in treatment failure. [0003] Recently, a number of drugs have been found to increase the sensitivity of tumor cells to nitrosourea anticancer drugs, see Dolan et al. "Effects of O6-benzylguanine analogues on the cytotoxic sensitivity of human tumor cells to alkylating agents" Cancer Research 51, pp. 3367-3372 (1991) (Dolan et al., Cancer Res., 5...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/17A61K45/06A61P35/00
Inventor 孔庆忠孙娟孔庆新苏红清孙静
Owner SHANDONG LANJIN PHARMA
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