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Colon soluble and intestine soluble hollow hard capsule and producing process

A hollow hard capsule and a production process technology, applied in directions such as capsule transportation, can solve the problems of difficult positioning and disintegration, cannot meet the needs of use, and the quality is not stable enough, and achieve the effects of simple and convenient production, low cost, and stable quality.

Inactive Publication Date: 2005-10-19
广东强基药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The disadvantages of the existing colonic-coated enteric-coated hollow hard capsules are that the quality is not stable enough, especially it is difficult to achieve positioning disintegration, and it cannot meet the needs of some drugs that need to be positioned to disintegrate in the human colon

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The colonic-coated enteric-coated hollow hard capsule of the present invention includes a skeleton layer and a coating film layer, and the skeleton layer includes the following components:

[0027] 1) At least gelatin, pectin, starch, water-soluble cellulose and its derivatives, agar gum, guar gum, carob gum, carrageenan, carrageenan, gum arabic, gum ghatti, gum tragacanth , Alan, xanthan gum, gellan gum, Konjac mannan, chitin; 2) sunscreen agent; 3) coloring agent; 4) surfactant; 5) water;

[0028] The coating layer includes the following components:

[0029] 1) At least one of acrylic material polymerization and copolymerization reactants, hydroxypropylmethylcellulose phthalate, polyethylene phthalate; 2) plasticizer; 3) organic solvent.

[0030] The above-mentioned acrylic acid material polymerization copolymerization reaction product comprises following components:

[0031] 1) There are at least two selected from methacrylic acid, methyl methacrylate, ethyl methac...

Embodiment 2

[0047] The components of the framework layer in this example are the same as those in Example 1, except that the coating solution for the coating film layer is made of 5%-10% acrylic acid copolymer, hydroxypropylmethylcellulose phthalate Hydrogen (HPMCP) 5%-10%, polyethylene phthalate (PVAP) 5%-10%, plasticizer 5%-10%, ethanol 30%-50%, acetone 10%-40%.

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Abstract

The present invention relates to colon soluble hard medicine capsule disintegrated in colon and its production process. The colon soluble hard hollow capsule includes skeleton layer and coating layer. The production process includes the following steps: dipping the skeleton layer material solution with mold and stoving; coating the skeleton layer material with coating layer; stoving and curing; demolding; cutting; matching; and inspection. The colon soluble hard hollow capsule has stable quality, may be disintegrated in fixed position, and suitable for colon administration. The hollow capsule may be filled with medicine, solid, liquid and soft matter, which are released in colon.

Description

1. Technical field: [0001] The invention relates to a medicinal hard capsule which is orally disintegrated in the colon of a human body and a production process, and belongs to the innovative technology of the colon-coated enteric-coated hollow hard capsule and the production process. 2. Background technology: [0002] The disadvantages of the existing colonic-coated enteric-coated hollow hard capsules are that the quality is not stable enough, especially it is difficult to achieve localized disintegration, and it cannot meet the needs of some medicines that need to be disintegrated in the human colon. 3. Contents of the invention: [0003] The purpose of the present invention is to provide a colonic-coated enteric-coated hollow hard capsule that is stable in quality, can realize localized disintegration, and is suitable for colon-specific drug delivery in consideration of the above problems. [0004] Another object of the present invention is to provide a simple and conve...

Claims

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Application Information

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IPC IPC(8): A61K9/48
Inventor 李加海陈坤昭李泳雪王春龙李煜龙许锐鹏许舜金许雄群
Owner 广东强基药业有限公司
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