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Danhong freeze dried powder injection agent and its preparation method

A technology for freeze-dried powder injection and injection, which is applied in the direction of freeze-dried transportation, medical preparations containing active ingredients, powder transportation, etc. It can solve the problems of low content of active ingredients, poor quality stability, and poor purification effect. Achieve the effect of exquisite and reasonable process route, efficient retention, and efficient active ingredients

Inactive Publication Date: 2005-10-26
邹巧根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Regarding Danhong Injection, the current standard adopts the process standard as follows: extract Danshen medicinal material with dilute alcohol, and then co-extract it with safflower, the purification effect is not good, and the content of active ingredients is not high, and the dosage form is injection water, with Problems such as inconvenient transportation and poor quality stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Prescription: Danshen 1500g, safflower 500g

[0026] 2. Extraction and preparation process:

[0027] 1), extraction:

[0028] Take Salvia miltiorrhiza, crush it into a coarse powder, soak it twice with 50% ethanol for 1.5 hours each time, filter, combine the filtrate, recover ethanol under reduced pressure, and obtain Salvia miltiorrhiza extract A; add 8 times the amount of water to the dregs, and decoct three times , 2 hours each time, filter, combine the filtrates, concentrate under reduced pressure to a relative density of 1.17 (50°C), add ethanol

[0029] When the alcohol content is 65%, adjust the pH to 8.5 with 20% NaOH, let it stand for 24 hours, filter, recover ethanol under reduced pressure, and concentrate to a relative density of 1.10 (50°C), adjust the pH to 1.7 with dilute hydrochloric acid, and centrifuge , the supernatant was extracted 3 times with an equal volume of ethyl acetate, the ethyl acetate extracts were combined, the ethyl acetate was recov...

Embodiment 2

[0035] 1. Prescription: Danshen 1500g, safflower 500g

[0036] 2. Extraction and preparation process:

[0037] 1), extraction:

[0038] Take Salvia miltiorrhiza, crush it into a coarse powder, soak it twice with 60% ethanol for 2 hours each time, filter, combine the filtrate, recover ethanol under reduced pressure, and obtain Salvia miltiorrhiza extract A; add 10 times the amount of water to the dregs, and decoct three times , 2 hours each time, filter, combine the filtrates, concentrate under reduced pressure to a relative density of 1.13 (50°C), add ethanol until the alcohol content is 65%, adjust the pH to 9.2 with 20% NaOH, let stand for 24h, and filter , recover ethanol under reduced pressure, and concentrate to a relative density of 1.11 (50°C), adjust the pH to 1-2 with dilute hydrochloric acid, centrifuge, extract the supernatant with an equal volume of ethyl acetate three times, combine the ethyl acetate extracts, The ethyl acetate was recovered, vacuum-dried and pu...

Embodiment 3

[0044] 1. Prescription: Danshen 1500g, safflower 500g

[0045] 2. Extraction and preparation process:

[0046] 1), extraction:

[0047] Take Salvia miltiorrhiza, crush it into coarse powder, soak it twice with 80% ethanol for 1.0 hour each time, filter, combine the filtrate, recover ethanol under reduced pressure, and obtain Salvia miltiorrhiza extract A; add 12 times the amount of water to the dregs, and decoct three times , 2 hours each time, filter, combine the filtrates, concentrate under reduced pressure to a relative density of 1.13 (50°C), add ethanol until the alcohol content is 65%, adjust the pH to 9.7 with 20% NaOH, let stand for 24h, and filter , recover ethanol under reduced pressure, and concentrate to a relative density of 1.14 (50°C), adjust the pH to 1.8 with dilute hydrochloric acid, centrifuge, extract the supernatant with an equal volume of ethyl acetate three times, combine the ethyl acetate extracts, and recover acetic acid Ethyl ester, vacuum-dried and...

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PUM

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Abstract

A freeze-dried powder injection for treating coronary heart disese, angina pectoris and cerebrovascular disease is prepared from red sage root and safflower through extracting in organic solvent, ultrafiltration for purifying, etc.

Description

technical field [0001] The invention relates to a medicine containing effective parts of salvia miltiorrhiza and safflower---danhong freeze-dried powder preparation for injection and a preparation method thereof. It belongs to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Salvia miltiorrhiza Bge. is the dried root and rhizome of Salvia miltiorrhiza Bge. Bitter in the mouth, slightly cold in nature. GUIXIN, Liver Channel. It has the effects of dispelling blood stasis and relieving pain, promoting blood circulation and promoting menstrual flow, clearing heart and eliminating troubles. It is used for irregular menstruation, amenorrhea, dysmenorrhea, accumulation of lumps in the abdomen, tingling pain in the chest and abdomen, heat arthralgia pain, sore swelling and pain, upset and insomnia, hepatosplenomegaly, angina pectoris, etc. [0003] Safflower is the dried flower of Carthamus tinctorius L., a plant of Compositae. Spicy i...

Claims

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Application Information

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Inventor 邹巧根王华娟
Owner 邹巧根
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