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Calcium sulphate based embedded type local medicine releasing system and preparation method

A calcium sulfate-based, calcium sulfate technology, applied in the field of biomedicine, can solve the problems of carrier material shedding, unstable drug release rate, PMMA can not be degraded, etc., to achieve the effect of controlling local release rate and overcoming unstable drug release rate

Inactive Publication Date: 2005-10-26
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotic streptomycin loaded with methyl methacrylate (PMMA) has been used in the treatment of osteomyelitis abroad, but PMMA cannot be degraded in the body, so a second operation is required to remove it
Calcium phosphate is used as the carrier, and its degradation rate is slow. Although calcium sulfate is used as the carrier, although the degradation rate is improved, the carrier material will fall off during use, which will cause the release rate to be unstable.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] Example 1 calcium sulfate / polyvinyl alcohol / metronidazole system

[0021] Take 10 parts of calcium sulfate, add 3 parts of metronidazole and mix evenly, then add polyvinyl alcohol saline solution with a weight of 1.5 parts of calcium sulfate, and stir fully, when the calcium sulfate is initially set, inject it into the mold, the calcium sulfate is fully Release the mold after solidification, and dry it in vacuum at 40°C to obtain a columnar or sheet-like implant sample. The polymer in the above carrier can be replaced by chitosan or sodium alginate.

example 2

[0022] Example 2 Calcium sulfate / carboxymethylcellulose (CMC) / antibiotic system

[0023] Dissolve 2 parts of CMC in normal saline to make a solution, then add 4 parts of gentamicin sulfate, mix well, dry under reduced pressure, concentrate and fully mix it with 10 parts of calcium sulfate, and then put the mixture into In the mold, it is shaped on a tablet press to obtain a columnar or sheet-like sample. It is also possible to directly mix 2 parts of CMC, 4 parts of gentamicin sulfate and 10 parts of calcium sulfate, then put the mixture into a mold, and shape it on a tablet machine to obtain a columnar or sheet-like implant sample. The polymer in the above carrier can be replaced by polyvinylpyrrolidone or polyethylene glycol, and gentamicin sulfate can be replaced by tobramycin or leucomycin.

example 3

[0024] Example 3 calcium sulfate / gelatin / doxorubicin system

[0025] Dissolve 2 parts of gelatin in physiological saline to make a solution, then add 0.02 parts of dispersant sodium dodecylsulfonate, 3 parts of doxorubicin, mix well and concentrate under reduced pressure, then add 10 parts of Calcium sulfate is thoroughly mixed, and finally it is poured in a mould, and after being fully condensed, the sample is taken out and dried to constant weight. The polymer in the above carrier can be replaced by polyvinylpyrrolidone, polyethylene glycol or carboxymethyl cellulose; the anticancer drug doxorubicin can be replaced by camptothecin or paclitaxel; into glyceryl stearate or span series surfactants.

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PUM

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Abstract

An implantative calcium sulfate-based local releasing system for treating chronic osteomyelitis and osteocarcinoma is proportionally prepared from calcium sulfate, polymer disperser, and medicine through mixing, adding physiologic soline, stirring, die pressing and vacuum drying.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to a calcium sulfate-based implanted local drug delivery system and a preparation method. Background technique [0002] The local drug release system has the characteristics of low toxicity and long drug effect. At present, domestic and foreign implant carrier materials are mostly polymers, such as polylactic acid and its copolymers, polycaprolactone, polyvinyl alcohol and various natural macromolecules, etc., and biological inorganic materials such as calcium phosphate can also be used. Drugs include anticancer drugs, antibiotics and protein drugs. For example, polyanhydride-loaded carbazide implant materials have passed FDA review in the United States for the treatment of glioma. Inorganic material-loaded anticancer drugs can be used as filling materials after bone cancer surgery, and simultaneously perform dual functions of bone repair and l...

Claims

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Application Information

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IPC IPC(8): A61K47/02
Inventor 高建平游秀东霍书娟刘宇
Owner TIANJIN UNIV
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