Mucolytic and anti-elastase compounds and methods of use thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- NAT JEWISH MEDICAL & RES CENT
- Publication Date
- 2005-11-09
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention generally relates to the use of a protein or peptide containing a reduced thioredoxin active site for inducing, enhancing and / or increasing the liquefaction of mucus or sputum. Background technique
[0002] Cystic fibrosis (CF) is a common fatal genetic disease that results from mutations in the gene encoding the regulator of CF transmembrane transduction, the chloride channel protein. Due to this defect, the epithelium in vivo is impermeable for chloride transport (Boucher et al., Lung 161: 1-17, 1983; Welsh, Physiol Rev 67: 11443-1184, 1987). Although several organs including the pancreas, intestine and male reproductive tract are affected, complications in the lungs account for 95% of morbidity and mortality (Means, M. Cystic Fibrosis: the first 50 years. In: Cystic Fibrosis-Current Topics Volume 1, edited by Dodge JA, Brock DJH, and Widdicombe JH. Chichester: Wiley and Sons, 1992, p. 217-250). In lungs affected by this disea...