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Medication for lowering level of endotoxin in human blood

An endotoxin and blood technology, applied in the field of medicine, can solve the problems of large oral dosage of Shuangligan granules, limited applicable patient population, and inapplicability.

Inactive Publication Date: 2005-11-16
韩德五
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the oral dosage of Shuangligan Granules is large, and it is not suitable for some patients with severe liver disease accompanied by gastrointestinal bleeding, which limits the applicable patient population of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Extraction of rhein: take 1000g of rhubarb coarse powder and put it in a 5000ml round bottom flask, add 1000ml of 20% sulfuric acid and 2000ml of ether, reflux in a water bath for 2 hours, pour out the extract, add 1000ml of 20% sulfuric acid and 1500ml of ether to the crude drug residue in the flask, The above method was used to extract twice, 1 hour each time, the extracts were combined, the ether layer was separated, and washed twice with water. Take 1000ml of the ether extract and place it in a 2000ml separating funnel, extract 3 times with 1000ml of 2.5% sodium bicarbonate aqueous solution, combine the sodium bicarbonate extract, add hydrochloric acid to acidify to pH 2-3 to obtain a yellow precipitate, filter the precipitate and recrystallize Get rhein solid. The filtered rhein was washed three times with distilled water. The product is dried in a vacuum drying oven, the dry product weight is 1.3g, and the color is light yellow, which is rhein dry powder.

[004...

Embodiment 2

[0047] The extraction of rhein and Danshensu is the same as in Example 1.

[0048] The medicine of the present invention is made of the following raw materials in weight ratio: 20 parts of rhein and 5 parts of danshensu.

Embodiment 3

[0050] The extraction of rhein and Danshensu is the same as in Example 1.

[0051] The medicament of the present invention is made of the following raw materials in the weight ratio: 10 parts of rhein and 10 parts of danshensu.

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PUM

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Abstract

A medicine for decreasing the content of endotoxin in human blood and treating endotoxemia, obstructive jaundice, pancreative and various shocks is prepared from rhein and danshensu.

Description

technical field [0001] The invention relates to a medicine, in particular to a medicine for reducing endotoxin level in human blood. Background technique [0002] The "gut-derived endotoxemia theory" believes that various factors causing liver injury (such as hepatitis virus, ethanol, drugs and hepatotoxic substances, etc.) cause "primary liver injury" through their respective etiology and pathogenesis, During the occurrence and development of liver diseases, most of the organisms have intestinal-derived endotoxemia (resulting in a substantial increase in the level of endotoxin in the human blood). A large number of studies have proved that gut-derived endotoxemia plays a decisive role in the occurrence and development of liver diseases, thus putting forward the "gut-derived endotoxemia theory". This theory was awarded the first prize of Shanxi Provincial Scientific and Technological Achievements in 1995 (No. 951011), and was reported on the front page of "Health News" (199...

Claims

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Application Information

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IPC IPC(8): A61K31/192
Inventor 韩德五赵正保周鑫赵海珍
Owner 韩德五
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