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Transdermal drug delivery system with improved water absorbability and adhesion properties

A drug delivery system and adhesive technology, applied in the field of release liner, which can solve the problems of poor adhesion and poor dissolution of acrylic adhesives

Inactive Publication Date: 2005-12-07
SAMYANG HLDG CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, despite these advantages, acrylic adhesives are poorly soluble in water and adhere poorly to sweat-wet skin

Method used

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  • Transdermal drug delivery system with improved water absorbability and adhesion properties
  • Transdermal drug delivery system with improved water absorbability and adhesion properties
  • Transdermal drug delivery system with improved water absorbability and adhesion properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-17 and comparative Embodiment 1

[0057] The transdermal drug delivery system was prepared according to the following method, and the composition of the matrix layer (2) is shown in Table 1-3.

[0058] Diclofenac diethylammonium salt, polyvinylpyrrolidone (Povidone 90F, Povidone 25K), colloidal silicon dioxide (Aerosil 380, 200, Degussa Company) were added to a 50 ml sample bottle. After adding the nonionic surfactant and ethanol, stir at 40°C until the pharmaceutical composition is completely dissolved. The mixture solution was cooled to room temperature, and an acrylate adhesive (National Starch & Chemical Company, Durotak TM , 87-2852, 87-2196, 87-4098). The resulting solution was stirred to mix all components in the vial and allowed to stand for 20 minutes to remove air bubbles. Then, with a laboratory coater and drier (Mathis company, Switzerland), the mixture is poured onto the backing film (1) and the release liner (3) to form adhesive layers (2a') and (2a " ), and dried at 80-120°C for 10 minutes. ...

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Abstract

The present invention relates to an adhesive based transdermal drug delivery system, having excellent water absorbability, comprising a backing film, an adhesive matrix containing active ingredients and a release liner which is peelable prior to use. The matrix layer of the present invention is a multilayered sandwich and comprises drug containing outer adhesive layers, adhering to the backing film and release liner respectively, between which is sandwiched an absorption enhancer layer. The adhesive layers comprise (a) an acrylate adhesive, (b) a mixture of high and low molecular weight polyvinylpyrrolidones, and (c) a colloidal silica.

Description

field of invention [0001] The present invention relates to adhesive-based transdermal drug delivery systems with improved water absorption and adhesive properties. Specifically, the present invention relates to an adhesive-based transdermal drug delivery system comprising a backing film, an adhesive matrix layer containing an active ingredient, and a release liner that can be peeled off before use. ). The matrix layer of the present invention is a multi-layer structure, including a drug-containing outer adhesive layer bonded to a backing film and a release liner respectively, with an absorption accelerator layer interposed therebetween. The adhesive layer included (a) an acrylate adhesive; (b) a mixture of high and low molecular weight polyvinylpyrrolidone, and (c) colloidal silica. The absorption enhancer layer contains nonionic surfactants, terpenes and dissolution aids. The transdermal drug delivery system of the present invention provides several desirable improvements:...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/00A61K9/70A61K31/05A61K31/196A61K45/06A61K47/02A61K47/04A61K47/06A61K47/10A61K47/14A61K47/16A61K47/18A61K47/22A61K47/32A61M37/00
CPCA61K9/7053A61K47/32A61K31/05A61K47/02A61K9/7061A61K31/196A61K45/06A61K9/70
Inventor 宋镇惪金东元
Owner SAMYANG HLDG CORP