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6-carboxy chitin, its preparation method and use

A technology of chitin and carboxyl group, applied in the field of polymer chemistry, can solve the problems of low preparation cost, low hyaluronic acid quantity and high price

Inactive Publication Date: 2006-01-11
SHENZHEN HEPALINK PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem of low quantity and high price of hyaluronic acid as a moisturizing agent, the object of the present invention is to provide a 6-carboxychitin that can replace hyaluronic acid and its preparation method and application. The 6-carboxychitin not only moisturizes The performance is comparable to that of hyaluronic acid, and the preparation method is simple and the preparation cost is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Soak chitin with a degree of deacetylation of 30% in warm water at 50° C. for 4 hours and dry. Get 1g of processed chitin and add it to 50ml distilled water, then add 12mg of Tempo, 0.4g of NaBr, then add 24ml of NaClO with a mass percentage concentration of 2%, then adjust the pH value to 10.8 with 0.5mol / L of NaOH, And keep 30min, finish reaction with the ethanol of 2.5ml, then adjust the pH value to neutrality with the HCl of 4mol / L, the solution obtained is dialyzed for 4 days, rotary evaporation concentrates, freeze-drying, obtains structural formula as (C 14 h 20 o 10 N 2 ) n , a degree of substitution of 0.3, a degree of deacetylation of 0.5, and a molecular weight of 18,000 6-carboxychitin. Its moisturizing properties are listed in Table 1.

Embodiment 2

[0013] Example 2: The raw material chitin with a degree of deacetylation of 30% is subjected to a deacetylation reaction to obtain a water-soluble chitin with a degree of deacetylation of 50%. Get 1g of treated water-soluble chitin and add it to 30ml distilled water, then add 9mg of Tempo, 0.3g of NaBr, then add 20ml of NaClO with a mass percentage concentration of 8%, and then adjust the pH value with 0.2mol / L NaOH 10.2, and kept for 30min, ended the reaction with 3ml of ethanol, then adjusted the pH value to neutrality with 4mol / L HCl, dialyzed the obtained solution for 4d, concentrated by rotary evaporation, and freeze-dried to obtain the structural formula (C 14 h 20 o 10 N 2 ) n , 6-carboxychitin with a degree of substitution of 0.7, a degree of deacetylation of 0.5, and a molecular weight of 35,000. Its moisturizing properties are listed in Table 1.

Embodiment 3

[0014] Embodiment 3: Chitosan is dissolved in the acetic acid solution of 20% (W / W), fully stirs after adding acetic anhydride, forms gel or clarification solution after standing; NH 4 OH precipitated, and the obtained product was repeatedly washed with 75% (W / W) ethanol solution, and dried in vacuum to obtain N-acetylated chitin. Get 1gN-acetylated chitin and add it to 60ml distilled water, then add 10mg of Tempo, 0.35g of NaBr, then add 28ml of NaCl with a mass percentage concentration of 4%, then adjust the pH value to 10.8 with 0.4mol / L of NaOH, And keep it for 1h, finish the reaction with 4ml of ethanol, then adjust the pH value to neutrality with 4mol / L of HCl, dialyze the solution obtained for 4d, concentrate by rotary evaporation, and freeze-dry to obtain the structural formula (C 14 h 20 o 10 N 2 ) n , a degree of substitution of 0.5, a degree of deacetylation of 0.3, and a molecular weight of 35,000 6-carboxychitin. Its moisturizing properties are listed in Tab...

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PUM

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Abstract

A 6-carboxychitin (C14H20O10N2)n with high hydroscopicity is prepared from chitin or chitosan through physical or chemical treating, and using NaC10 or NaBr to oxidize the hydroxy at C-6 site under existence of TEMPO to become carboxy and obtain water-soluble 6-carboxychitin. It can be used for cosmetics and medicines.

Description

technical field [0001] The invention relates to a 6-carboxychitin which can replace hyaluronic acid, a preparation method and application thereof, and belongs to the field of polymer chemistry. Background technique [0002] Hyaluronic acid is known as "moisturizing gold". Due to its excellent moisturizing properties, it is widely used in cosmetics and clinical medicine. Although hyaluronic acid is widely distributed in nature, the total amount is very small, so it is expensive. Contents of the invention [0003] In order to solve the problem of low quantity and high price of hyaluronic acid as a moisturizing agent, the object of the present invention is to provide a 6-carboxychitin that can replace hyaluronic acid and its preparation method and application. The 6-carboxychitin not only moisturizes The performance is comparable to that of hyaluronic acid, and the preparation method is simple and the preparation cost is low. [0004] The technical scheme provided by the in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
Inventor 杜予民孙立苹
Owner SHENZHEN HEPALINK PHARMA GRP CO LTD
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