Gold nanometer particle grain size control method based on glutathione

A technology of gold nanoparticles and glutathione, applied in the field of nanometers, can solve the problems of low biocompatibility of gold nanoparticles, narrow controllable size range of gold nanoparticles, etc., and achieve easy promotion and application, and convenient and adjustable particle size , high efficiency effect

Inactive Publication Date: 2006-02-22
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the biocompatibility of gold nanoparticles prepared by this method ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1 ml of 1% (w / v) chloroauric acid solution was added to 79 ml of ultrapure water (a solution). Get trisodium citrate solution and oxidized glutathione solution, add ultrapure water to 20ml (b solution), control the mass ratio of glutathione and chloroauric acid to be 0.1:1, trisodium citrate and chloroauric acid The mass ratio of acid is 3:1. Heat both solutions a and b to 60°C, then quickly pour solution b into solution a and mix. After the color of the mixed solution changed, the solution was heated to boiling. Keep boiling for 15 minutes to make the reaction fully, and then cool the solution to obtain a 38nm gold nanoparticle sol solution with a volume distribution of 91.6%.

Embodiment 2

[0018] Add 1 ml of chloroauric acid solution to 79 ml of ultrapure water (a solution). Get trisodium citrate solution and reduced glutathione solution, add ultrapure water to 20ml (b solution), control the mass ratio of glutathione and chloroauric acid to be 0.5:1, trisodium citrate and chloroauric acid The mass ratio of acid is 4:1. Heat both solutions a and b to 75°C, then quickly pour solution b into solution a and mix. After the color of the mixed solution changed, the solution was heated to boiling. Keep boiling for 5 minutes to make the reaction fully, and then cool the solution to obtain 8nm gold nanoparticle sol solution with a volume distribution of 97.6%.

Embodiment 3

[0020] Add 1 ml of chloroauric acid solution to 79 ml of ultrapure water (a solution). Get trisodium citrate solution and oxidized glutathione solution, add ultrapure water to 20ml (b solution), control the mass ratio of glutathione and chloroauric acid to be 0.8:1, trisodium citrate and chloroauric acid The mass ratio of acid is 4:1. Heat both solutions a and b to 50°C, then quickly pour solution b into solution a and mix. After the color of the mixed solution changed, the solution was heated to boiling. Keep boiling for about 8 minutes to make the reaction fully, and then cool the solution to obtain a 15nm gold nanoparticle sol solution with a volume distribution of 99.2%.

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Abstract

Disclosed is a method for controlling the grain diameter of gold nanometer particles with glutathion, belonging to the field of nanometer technology. The specific steps are as following: a. mixing the citric acid trisodium solution with glutathion solution; b. heating separately the solution prepared by step-a and chlorauric acid solution, then mixing; c. heating the solution to boiling to make the reaction complete after the solution prepared by step-b off-color, then cooling the liquid to prepare gold nanometer particle sol solution. The method is characterized in that: it is simple and the efficiency is high, the particle dimension is easy to adjust, and the creature compatibility is good, and the prepared nanometer particles has a good dispersibility and a uniform grain diameter which can be controlled by a range of 8-40nm. The gold nanometer particles can apply in the field of DNA detection, biology, drug industry, and so on.

Description

technical field [0001] The invention relates to a method in the field of nanotechnology, in particular to a method for controlling the particle size of gold nanoparticles based on glutathione. Background technique [0002] In recent years, with the rise of nanotechnology, nanoscale gold particles have shown potential application value in many fields due to their unique optical and electrical properties, which has aroused people's strong research interest. The size and size of gold nanoparticles strongly affect their potential applications in chemistry, biology, and electronic devices. When the particle is smaller than 100nm, its optical, electrical and magnetic properties strongly depend on the particle size, so the desired physical properties can be obtained indirectly by controlling the particle size of gold nanoparticles. There are many methods to control the particle size of gold nanoparticles, such as liquid phase extraction, seed crystal method, electrochemical method...

Claims

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Application Information

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IPC IPC(8): B22F9/24
Inventor 王英杨明来朱林佩张亚非
Owner SHANGHAI JIAO TONG UNIV
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