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Process of extracting secoiridoid glycoside product from medicinal plant gentian

The technology of split iridoid and medicinal plant is applied in the field of extraction technology of effective components of Chinese herbal medicine, and achieves the effects of good repeatability, convenient operation and simple process

Inactive Publication Date: 2006-03-01
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The extraction and separation of water-soluble components of natural products, macroporous resin adsorption method is a very effective industrial production method, the industrialization of extracting secoiridoid glycosides (picrosides) from Gentiana medicinal plants by using adsorption resin The production method has not yet been reported in relevant literature and patents at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: A kind of process of extracting secoiridoid glycosides product from Gentiana medicinal plant Gentiana gentiana plant, comprises the following steps: first use 20-95% methanol aqueous solution in the dry root of Gentiana genus genus plant 50-80 ° C, successively decrease the amount of reflux extraction three times, each time for 2-4 hours, filter and recover the methanol solution to obtain the extract of secoiridoid glycosides, and combine and concentrate the three reflux extracts; to the moderately concentrated Add an appropriate amount of water to the extract to obtain a turbid solution, and let it stand at room temperature for 24-48 hours, filter or centrifuge to remove the flocculated fat-soluble components to obtain a clear solution, and concentrate until dry to obtain a split terpene glycoside product. The content of secoiridoid glycosides is greater than 15%.

Embodiment 2

[0014] Embodiment two: a kind of technology that extracts split iridoid glycosides product from Gentianaceae medicinal plant Gentiana genus Gentiana plant, comprises the following steps: (1) the dried stem of Gentiana genus Gentiana plant is mixed with methanol solution at 50- 80 DEG C successively decrease the amount of reflux extraction three times, each time for 2-4 hours, filter and recover the methanol solution to obtain the extract of secoiridoid glycosides, and combine and concentrate the extracts of three times of reflux; (2) after moderate concentration Add an appropriate amount of water to the extract to obtain a turbid solution, and refrigerate and stand at 0-4°C for 24-48 hours, filter or centrifuge to remove the flocculated fat-soluble components to obtain a clear solution; (3) a certain amount of macroporous adsorption resin, with An appropriate amount of ethanol is swelled and eluted with water to gradually transition to the water phase, and transferred to a chro...

Embodiment 3

[0015] Embodiment three: a kind of technology that extracts split iridoid glycosides product from Gentianaceae medicinal plant Gentiana genus Gentiana plant, comprises the following steps: (1) the dried stem of Gentiana genus Gentiana plant is mixed with methanol solution at 50- 80 DEG C successively decrease the amount of reflux extraction three times, each time for 2-4 hours, filter and recover the methanol solution to obtain the extract of secoiridoid glycosides, and combine and concentrate the extracts of three times of reflux; (2) after moderate concentration Add an appropriate amount of water to the extract to obtain a turbid solution, and let it stand at room temperature for 24-48 hours, filter or centrifuge to remove the flocculated fat-soluble components to obtain a clear solution; (3) add a certain amount of macroporous adsorption resin with an appropriate amount of alcohol Swelling and eluting with water, making it gradually transition to the water phase, and transfe...

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Abstract

The present invention relates to the technological process of extracting secoiridoid glycoside product from medicinal plant gentian. Gentian herb or its root, leaf and flower as material is reflux extracted with hydrophilic solvent, separated and enriched with macroporous resin with selective adsorption on water soluble components, to obtain secoiridoid glycoside product with secoiridoid glycoside content over 20 %. The technological process of the present invention is simple, easy in operation, safe and high in repeatability, and may be used in industrial production.

Description

technical field [0001] The invention relates to a process for extracting effective components of Chinese herbal medicines, in particular to a process for extracting secoiridoid glycosides (picrosides) products from Gentiana medicinal plants. Background technique [0002] The main medicinal plants in the genus Gentiana are Gentiana, Gentiana, Gentiana, Gentiana, and Gentiana. Qinghai-Tibetan gentian, Wunu gentian, and alpine gentian are mostly used as medicines with roots, flowers or whole plants, which have multiple functions such as dispelling rheumatism, clearing damp-heat, relieving numbness and pain, clearing away heat and detoxifying. It is clinically used for the treatment of various diseases such as muscle spasm, joint pain, malnutrition and fever in children, jaundice [see Pharmacopoeia of the People's Republic of China, 2000 edition, pages 222-223; Drug Standards of the Ministry of Health of the People's Republic of China, Tibetan A volume of medicine, 1992; pp. 17...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08
Inventor 纪兰菊陈桂琛吉文鹤卢学峰孙洪发
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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