Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method of producing reduced coenzyme q10 as oily product

A reduced type, coenzyme technology, applied in organic chemistry, quinone separation/purification, etc., to achieve the effect of reducing operation time and reaction time

Inactive Publication Date: 2006-04-26
KANEKA CORP
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Therefore, it is required to have a direct and simple way to obtain reduced coenzyme Q 10 A method that does not require some additional operations, such as extraction and concentration from the organic phase, and / or a method that contains reduced coenzyme Q 10 The method of distilling off the organic solvent from the organic phase of the organic phase, which uses a simple method and a short time, and does not cause the failure of stirring

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0149] Further illustrate the present invention below, but these examples in no way have any limitation to the scope of the present invention, in this example, reduced coenzyme Q 10 Purity and Reduced Coenzyme Q 10 / oxidized coenzyme Q 10 The weight ratio of is determined by the specific HPLC analysis described below. However, the measured reduced coenzyme Q 10 The purity of is by no means a limitation on the purity values ​​obtained in accordance with the present invention. Similarly, the resulting reduced coenzyme Q 10 / oxidized coenzyme Q 10 The weight ratio value does not represent the upper limit of the ratio.

[0150] (Conditions of HPLC) column: SYMMETRY C18 column (product of Waters Company), 250mm (length), 4.6mm (inner diameter); Mobile phase: ethanol: methanol=4: 3 (v / v); Detection wavelength: 210nm; Flow rate: 1ml / min; reduced coenzyme Q 10 Retention time: 9.1min; oxidized coenzyme Q 10 Retention time: 13.3min.

example 1

[0152] oxidized coenzyme Q 10 (100 g; purity 99.4%) was stirred and melted at 50°C. When stirring (power required for stirring: 0.3kw / m 3 ), the prepared aqueous solution is gradually added to the oily product, and the reduction reaction is carried out at 50° C. and a pH value of 4 to 6. The aqueous solution is 100 g of sodium dithionite (purity: at least 75%) dissolved in Prepared in 1000ml of water. After two hours, stir (power required for stirring: 0.3kw / m 3 ), and the mixture was cooled to 2° C. to obtain a white crystalline slurry (flowable crystalline slurry is better). All the above operations were done under nitrogen atmosphere. The obtained crystalline slurry was filtered under reduced pressure, and the wet crystals were rinsed sequentially with cold water and cold ethanol (the temperature of the cold solvent used for washing was 2° C.), and then the wet crystals were dried under reduced pressure (20 to 40° C., 1 to 30 mmHg), 98k of white dry crystals were obtai...

example 2

[0154] oxidized coenzyme Q 10 (100 g; purity 99.4%) was stirred and melted at 50°C. While stirring (power required for stirring: 0.3kw / m3), gradually add the prepared aqueous solution to the oily product, so that the reduction reaction is carried out at 50°C and a pH value of 4 to 6. The aqueous solution is the reducing agent Prepared by dissolving 100 g of sodium dithionite (purity: at least 75%) in 1000 ml of water. After two hours, the aqueous phase that contains oily product is removed from reaction mixture, then adds the ethanol that 1400g is heated to 50 ℃ in aqueous phase, stirs (stirring required power: 0.3kw / m 3 ), and the mixture was cooled to 2° C. to obtain a white crystalline slurry (flowable crystalline slurry is better). All the above operations were done under nitrogen atmosphere. The obtained crystalline slurry was filtered under reduced pressure, and the wet crystals were rinsed sequentially with cold water and cold ethanol (the temperature of the cold sol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for preparing reduced coenzyme Q10. Reduced coenzyme Q10 can be used as beneficial food, functional nutritional food, special health food, nutritional supplement, nutrient, beverage, feed, cosmetics, medicine, therapeutic drug, preventive The components of medicine etc., the method is suitable for high-quality and high-efficiency industrial production. High quality oily reduced coenzyme Q10 has low viscosity and is easy to handle, it is prepared by separating the aqueous phase from the reaction mixture obtained by the oily reaction of oxidized coenzyme Q10 and reducing agent in water, or by measuring the melting point or melting point of reduced coenzyme Q10 Concentrate the organic phase containing reduced coenzyme Q10 at the above temperature to remove the organic solvent coexisting therein. In addition, a solution or slurry of reduced coenzyme Q10 can be obtained by adding a desired solvent to the obtained oily product, or a solid reduced coenzyme Q10 can be prepared by adding seed crystals to the oily product.

Description

[0001] The application number is 02817399.6, the application date is July 15, 2002, and the title of the invention is "preparation of reduced coenzyme Q 10 A divisional application of the patent application for "method for oily products". technical field [0002] The invention relates to a method for preparing reduced coenzyme Q 10 (reduced coenzyme Q 10 )Methods. oxidized coenzyme Q 10 Compared to reduced coenzyme Q 10 Show higher oral absorption rate, and the compound can be used as beneficial food, functional nutritional food, special health food, nutritional supplement, nutrients (nutrients), beverage, feed, cosmetics, medicine (medicines), therapeutic drug ( remedies), prophylaxis, etc. Background technique [0003] Known reduced coenzyme Q 10 The preparation method is as follows, coenzyme Q is prepared by conventional methods, such as synthesis, fermentation, or extraction from natural products 10 , and then concentrated to produce reduced coenzyme Q containing ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C50/28C07C43/23C07C46/10
Inventor 植田尚宏北村志郎上田恭义
Owner KANEKA CORP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com