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Vitamine U, belladonna and aluminiium dispersible tablet and its preparation process

A technology of dispersible tablets and belladonna, applied in the field of medicine, can solve the problems of affecting the rapid effect of the drug, slow disintegration speed, long time for relieving stomach pain, gastric acid, and stomach distension, etc., and achieves inhibition of smooth muscle spasm and disintegration speed. Enhanced, fast-acting results

Inactive Publication Date: 2006-05-03
XIUZHENG PHARMA GROUP HOIDING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this product is a capsule, and the capsule has the disadvantage of slow disintegration speed. The disintegration time limit of the capsule is generally 10-40 minutes. Due to the common phenomenon of serious aging in the capsule, after one and a half years of storage, the time limit for the disintegration of the capsule shell Generally more than 40 minutes, the time to reach the peak is longer, which affects the rapid effect of the drug and has a certain impact on the absorption of the drug. It takes a long time for patients to relieve stomach pain, gastric acid, and bloating; quickly eliminate stomach pain, gastric acid, The key to the symptoms of gastric distension is that the disintegration and dissolution time of the drug in the stomach should be short. Therefore, a new drug in the form of vitamin U belladonna aluminum dispersible tablets was developed to shorten the time limit for disintegration of the drug and quickly alleviate the symptoms of stomach problems. pain, significant

Method used

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  • Vitamine U, belladonna and aluminiium dispersible tablet and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Take 50g vitamin U II, 140g aluminum hydroxide, 10g belladonna extract (calculated as atropine sulfate, not less than 0.15mg), 50g starch, 30g microcrystalline cellulose, 25g sodium carboxymethyl starch, 2g talcum powder, hard 2g magnesium fatty acid is made into 1000 tablets;

[0048] The preparation process is:

[0049] (1) Crush the raw materials and auxiliary materials separately, and pass through a 100-mesh sieve; weigh vitamin U II, aluminum hydroxide, belladonna extract and appropriate amount of starch according to the prescription, mix and absorb, and sieve and mix evenly;

[0050] (2) Take the prescription amount of vitamin U II, aluminum hydroxide and the above belladonna extract and mix them evenly by equal increasing method;

[0051] (3) Mix the mixed main medicine and internal auxiliary materials uniformly by equal increment method;

[0052] (4) The above mixture is made into a soft material with 10% starch slurry, and granulated with a 20-mesh screen; the wet ...

Embodiment 2

[0055] Take 50g vitamin U II, 140g aluminum hydroxide, 10g belladonna extract (calculated as atropine sulfate, not less than 0.15mg), 55g starch, 25g microcrystalline cellulose, 15g sodium carboxymethyl starch, plus carboxymethyl 5g of sodium starch, 2g of talc and 2g of magnesium stearate are made into 1000 tablets;

[0056] The preparation process is the same as in Example 1.

Embodiment 3

[0058] Take 50g vitamin U II, 140g aluminum hydroxide, 10g belladonna extract (calculated as atropine sulfate, not less than 0.15mg), 60g starch, 20g microcrystalline cellulose, 10g sodium carboxymethyl starch, plus carboxymethyl 5g sodium starch and 3g magnesium stearate are made into 1000 tablets;

[0059] The preparation process is the same as in Example 1.

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Abstract

The invention provides an improved process for preparing vitamin U, belladonna and aluminium dispersible tablet by using vitamin U II, aluminum hydroxide and belladonna extract as raw material, starch as bulking agent, crystalline cellulose, sodium carboxymethylstarch, talcum powder and magnesium stearate as the auxiliary material.

Description

Technical field [0001] The invention belongs to the field of medical technology, and specifically relates to vitamin U belladonna aluminum dispersible tablets and a preparation process thereof. The international patent classification number is A61K 9 / 00. Background technique [0002] At present, the drug Vitamin U Belladonna has a good effect on the treatment of stomach pain, gastric acid and bloating, and its trade name is Sidashu, which is very popular among patients. However, the product is a capsule. The capsule has the disadvantage of slow disintegration. The disintegration time of the capsule is generally 10-40 minutes. Due to the serious phenomenon of aging in the capsule, the time limit for the capsule shell to disintegrate after storage for one and a half years Generally more than 40 minutes, the peaking time is longer, and the effect of the drug is affected quickly. It has a certain impact on the absorption of the drug. It takes longer for the patient to relieve stomach...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K9/20A61K31/195A61K31/46A61K36/81A61P1/04
Inventor 张德桐张显涛王鑫高爽
Owner XIUZHENG PHARMA GROUP HOIDING
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