New formulation oxaliplatin liposome
A technology of oxaliplatin and liposomes, which is applied in the field of medicine, can solve the problems of preparations such as high irritation, poor quality, and high production costs, and achieve the effects of improving curative effect and poor oral absorption
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[0011] Example 1:
[0012] Preparation of oxaliplatin liposomes by ethanol injection method: dissolve soybean phospholipids, cholesterol, VE and anhydrous ethanol, then inject into oxaliplatin aqueous solution, stir at constant temperature and high speed, evaporate under reduced pressure to remove ethanol, and granulate through microporous membrane , The oxaliplatin liposome is obtained, and the encapsulation rate can reach 72.8%.
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[0013] Example 2:
[0014] Thin film dispersion method to prepare oxaliplatin liposomes: take soybean phospholipids, cholesterol, and VE, dissolve 15ml chloroform in a 150ml eggplant-shaped bottle, form a film under reduced pressure on a rotary thin film evaporator and remove organic solvents, add 10ml oxa The liplatin aqueous solution is hydrated and granulated through a microporous filter membrane to obtain oxaliplatin liposomes with an encapsulation rate of 70.1%.
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[0015] Example 3:
[0016] Preparation of oxaliplatin liposomes by reversed-phase evaporation method: Weigh soybean phospholipids, cholesterol, VE, add 5ml chloroform to dissolve, then add 10ml ether, then add 15ml oxaliplatin phosphate buffer, bath ultrasonic A homogeneous single-phase system is formed, the chloroform ether is removed by evaporation under reduced pressure until the gel is formed, and the evaporation under reduced pressure is continued for 5-10 minutes, and the aqueous suspension is vortexed until the liposome is formed. The encapsulation rate can reach 37.5%.
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