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Process for producing kuh-seng total flavone and flavone salt by kuh-seng

A technology of total flavonoids of Sophora flavescens and Sophora flavescens, which is applied in the directions of antitoxins, antitumor drugs, organic chemistry and the like, and achieves the effects of low cost of raw materials, increased lipophilicity and simple process

Inactive Publication Date: 2006-06-28
SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Flavonoid salt products have the biological activity of flavonoids, relatively stable chemical properties, can be compatible with alkaline drugs, and are easy to store. There are no reports about their products or production processes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 〔1〕Add 100g of Sophora flavescens powder of 10-40 meshes to 300ml of methanol, extract by ultrasonic vibration for 30min, stand still, filter, wash the filter cake with methanol until it is colorless and free of alkaloids; filter, concentrate the filtrate to 100ml, add 400ml of water, flavonoids Substances were precipitated and filtered.

[0034] [2] Distilled under reduced pressure to obtain a yellow powder product, which contains 80% (UV) of total flavonoids after testing.

Embodiment 2

[0036] [1] Add 100g of 40-80 mesh flavescens powder to 300ml of ethanol-ammonia solution, alcohol:ammonia = 100:0.2 (ml / ml), percolate until the extract is colorless and free of alkaloids, concentrate the extract to 100ml, add 400ml of water, flavonoids precipitated, filtered.

[0037] [2] Spray drying to obtain a yellow powder product, which contains 82% (UV) of total flavonoids after testing.

Embodiment 3

[0039] [1] Add 100g of 80-100 mesh Sophora flavescens powder to 300ml of ethanol-hydrochloric acid (10%) solution, alcohol: hydrochloric acid = 100:1 (ml / ml), stand for extraction, filter, and repeat the extraction of the filter cake until the extract is colorless And without alkaloids, the extracts were combined and concentrated to 100ml, added with 600ml of water, flavonoids were precipitated, and filtered.

[0040] [2] Freeze-dry the flavonoid-enriched phase to obtain a yellow powder product, which contains 85% (UV) of total flavonoids after testing.

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Abstract

The invention relates to a method to produce kuhseng omniflavone from kuhseng that mixes 10-120 items of kuhseng with solution and the ratio is 1g: 3-10ml. Distilling the kuhseng biology alkali and kuhseng omniflavone constituent, filtering, fully separating, drying, the product would be gained. The method has low cost raw material, simple technology, and high content.

Description

technical field [0001] The invention relates to a method for producing total flavonoids and flavone salts of Sophora flavescens. technical background [0002] Flavonoids are a class of natural products that exist widely in nature, and their basic core is 2-phenylchromones, which refer to two benzene rings (A, B rings) with phenolic hydroxyl groups connected to each other through the central three carbon atoms. A series of compounds can be divided into flavonoids, flavonols, dihydroflavones, dihydroflavonols, anthocyanins, chalcones, and dihydrochalcones according to the difference of the central 3-carbon chain. , isoflavones, dihydroisoflavones, etc. Experiments have proved that flavonoids have the following effects on animals and humans: ① anti-oxidation and scavenging free radicals; ② synergistic effect on vitamin C; Damaged by carcinogens, inhibiting tumor cell proliferation and anti-free radicals, it has anti-cancer effects; ④ can chelate with metals, protect the activi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/04A61P35/00A61P39/00A61P39/06C07D311/30C07D311/32C07D311/36C07D311/38C07D311/62
Inventor 侯相林刘鹏飞邓天昇
Owner SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI