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Extract from plant of japanese parsley family and process for producing the same

A technology for extracts and plants, which is applied to the field of extracts of cress family plants and their preparation, and can solve problems such as the inability to show therapeutic effects and the like

Inactive Publication Date: 2006-07-26
TAKARA HOLDINGS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in patients with type II diabetes, for those with insulin resistance mainly caused by hyperinsulinemia, insulin receptor abnormality, abnormality of insulin receptor downstream signaling, etc., sometimes even if insulin is administered or insulin secretory Accelerators also failed to show a therapeutic effect

Method used

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  • Extract from plant of japanese parsley family and process for producing the same
  • Extract from plant of japanese parsley family and process for producing the same

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0043] The preparation of the therapeutic or preventive drug of the present invention can usually be carried out by combining the above-mentioned active ingredients with a pharmaceutically acceptable liquid or solid carrier, and if necessary, solvents, dispersants, emulsifiers, buffers, and stabilizers can also be added. , excipients, binders, disintegrants, lubricants, etc., made into solid preparations such as tablets, granules, powders, powders, capsules, and liquid preparations such as conventional liquids, suspensions, and emulsions. In addition, it can also be made into a dry product or other external medicines that can be made into a liquid by adding an appropriate carrier before use.

[0044] The pharmaceutical carrier can be selected according to the administration method and dosage form of the therapeutic drug or preventive drug. When made into an oral preparation containing a solid composition, it can be made into tablets, pills, capsules, powders, fine granules, gr...

Embodiment 1

[0081] 40 mL of extraction solvents (40, 50, 60, 70, 80% ethanol aqueous solution and 100% ethanol) were added to 2 g of the ground freeze-dried product of the stem and leaf part of Angelica sinensis, and extraction was carried out at 25° C. for 30 minutes. The content of chalcones in the centrifuged supernatant was measured by HPLC. As a column, TSK gel ODS-80Ts QA (4.6 mm×25 cm: manufactured by Tosoh Corporation) was used. Solvent A (a mixed solvent of distilled water and acetonitrile at a volume ratio of 4:1, and containing 0.1% trifluoroacetic acid) and solvent B (a mixed solvent of distilled water and acetonitrile at a volume ratio of 1:9, and containing 0.1% trifluoroacetic acid ) linearly varied the ratio of solvent B from 0 to 100% from 0 to 45 minutes, followed by maintaining the ratio of solvent B at 100% for 10 minutes. The elution rate was 1 mL / min, and the detection was carried out at 215 nm and a column temperature of 30°C.

[0082] The results are shown in Tab...

Embodiment 2

[0086] The same extraction as in Example 1 was performed on the pulverized product of the freeze-dried product of the root of Angelica sinensis, and the amount of chalcones in the extract was measured. The results are shown in Table 2. It can be seen from Table 2 that when extracting TB1 and TB2 from the roots of Angelica sinensis, the extraction efficiency of aqueous ethanol is better than that of 100% ethanol. In addition, it is also clear that 60%, 70%, and 80% ethanol aqueous solutions are more efficient than 100% ethanol when extracting yellow angelica alcohol and 4-hydroxydrysin from the root of Angelica sinensis.

[0087] extraction solvent

[0088] Express the amount extracted by 100% ethanol extraction as 100%

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PUM

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Abstract

The present invention provides an extract obtained by extracting a plant of the Japanese parsley family or treatment product thereof with an aqueous alcohol; a process for producing the extract; a therapeutic agent or preventive for diabetic complications and / or diseases accompanied by inflection of insulin level or insulin response, characterized by containing the above extract as an active ingredient; an insulin-like acting agent characterized by containing the above extract as an active ingredient; a food, drink or feed characterized by containing the above extract; a promoter of glucose intake in cells characterized by containing the above extract as an active ingredient; a differentiation inducer to fat cells characterized by containing the above extract as an active ingredient; and an aldose reductase inhibitor characterized by containing the above extract as an active ingredient.

Description

technical field [0001] The present invention relates to an extract from plants of the cressaceae plant containing a large amount of physiologically active components, a preparation method thereof, and medicine, food, beverage or feed containing the extract. Background technique [0002] Angelica is a large perennial herb in the cress family known to have a variety of health-promoting effects. For example, as the physiological activity of Angelica sinensis, it is known that there are antibacterial effect, antitumor effect, gastric acid secretion inhibitory effect, anticancer effect, effect of enhancing nerve growth factor production, and effect of enhancing hepatocyte proliferation factor production (for example, refer to International published brochure No. 01 / 76614). However, the effects of insulin such as antidiabetic effects and antiobesity effects have not been known so far. [0003] Insulin is a hormone necessary for normal carbohydrate, protein and fat metabolism in ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/08A61P3/10A61P5/48A61P43/00A23L1/30A23K1/16C12N9/99A61K36/23A61K36/232
CPCA23V2002/00A61K36/232A23K1/1646A61K36/23A23L1/3002A23K20/10A23L33/105A61P3/04A61P3/06A61P3/08A61P3/10A61P5/48A61P9/02A61P9/04A61P9/10A61P9/12A61P13/12A61P21/00A61P25/00A61P25/02A61P25/14A61P25/18A61P25/28A61P25/36A61P27/02A61P27/12A61P27/16A61P31/00A61P35/00A61P43/00A23V2200/328A23V2250/21
Inventor 大野木宏杉山胜美村木信子榎龙嗣佐川裕章加藤郁之进
Owner TAKARA HOLDINGS
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