16 alpha-bromosteroid compound and its synthesis method
A technology of steroid compound and synthesis method, which is applied in the field of a class of 16α-bromo steroid compound and its synthesis, and can solve the problem of no literature report and the like
Inactive Publication Date: 2006-09-13
SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
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Problems solved by technology
The invention relates to 16alpha-bromization steroid compounding and the synthetic method. When the pregnant sterol and the acetlyation bromization reagent have the reaction of the regioselective acetylation,a series of 16alpha-bromization steroid compound of the novel fabric are gained. The formula of the steroid compound is the above formula, so represents the turning up or the adown; R1 is H, OH, 0Ac, OMOM or OTBDPS; R2 is H or Br; R3 is H, Br or R3 and R4 form the 5,6-double bond; R4 is H or Br; R5 is H, OH, Oac or OMOM; thereinto, Ac is the acetyl, TBDPS is the tertiary diphenyl silicone base, MOM is the methoxy methylene. The method provided by the invention is simple, fit for the industrialized produce and makes it possible to utilize effectively the pregnant sterol (the degradation product of the steroid sapogenines).
Double bondRegioselectivity +6
- Experimental program(7)
Description & Claims & Application Information
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