Amoxicillin antibacterial agent containing nano silver, and its preparing method and use

A technology of amoxicillin and nano-silver, which is applied in the field of biomedicine, can solve the problems of increased drug side effects and failure to significantly improve the efficacy of antibacterial agents, etc., and achieves easy-to-obtain raw materials, is conducive to industrialization and commercialization, and has broad development prospects and the effect of applying space

Inactive Publication Date: 2006-10-25
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods solve the problem of drug resistance to a certain extent, but fail to significantly improve the efficacy of antibacterial agents, especially with the entry of some organic components, the side effects of drugs on the human body also increase

Method used

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  • Amoxicillin antibacterial agent containing nano silver, and its preparing method and use
  • Amoxicillin antibacterial agent containing nano silver, and its preparing method and use
  • Amoxicillin antibacterial agent containing nano silver, and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Preparation of nano silver

[0026] At normal temperature and pressure, to a concentration of 0.01mol / L AgNO 3 The solution is injected with ammonia gas to maintain the pH of the solution=12, and then [Ag(NH 3 ) 2 ]+ solution and 5% (wt%) sodium dodecyl sulfate (SDS) aqueous solution are mixed in equal volumes into a conical flask and placed on a magnetic stirrer at a temperature of 70°C. Add vitamin C (concentration: 0.01mol / L) drop by drop with a medical infusion set, while keeping the rotating speed of the stirring bar at 120 rpm, and react for 2 hours. Use alcohol as a solvent to centrifuge and wash the precipitate (repeat several times to remove the surfactant), and then vacuum dry to obtain nano silver.

[0027] (2) Nano silver and amoxicillin antibacterial performance test (minimum inhibitory concentration test)

[0028] In the antibacterial test, the test strain (Escherichia coli F220) was activated in LB medium at 37° C., and then cultivated until the a...

Embodiment 2

[0035] Under the same conditions, add 1ml of mixed solutions of different concentrations of nano-silver and amoxicillin, 0.15mg / ml amoxicillin+10μg / ml nano-silver, to an equal amount of bacterial strains, and stir for 10 minutes to obtain the product. Figure 4 It can be seen that the synergistic antibacterial effect of amoxicillin and nano-silver is far better than that of amoxicillin and nano-silver alone.

Embodiment 3

[0037] Utilize commercially available nano-silver (particle diameter is 30-40nm) to be formulated into the silver colloid dispersion liquid of 10 μ g / ml and the powder (specification 0.125g / grain) in the commercially available amoxicillin capsule is formulated into the solution mixing of 0.25mg / ml, The mass ratio of nano-silver and amoxicillin is 1:10, and the product is obtained by stirring for 8 minutes, and the combined antibacterial also obtains satisfactory results.

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Abstract

The present invention relates to an amoxicillin antimicrobial containing nano silver. its preparation method and application. At the normal temperature the nano silver and amoxicillin are uniformly mixed so as to obtain the invented amoxicillin antimicrobial containing nano silver. The tests show that said invention has stronger antimicrobial effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an amoxicillin antibacterial agent containing nano-silver and a preparation method and application thereof. Background technique [0002] β-lactams (β-lactam) and sulfonamides are relatively broad-spectrum antibiotics. Due to repeated application for a long time, a large number of bacteria have strong resistance to such antibacterial agents. Therefore, in daily life and medical treatment, increasing the dose of antibacterial agents is usually used to achieve a satisfactory antibacterial effect. The consequence of doing this can only be to continuously increase the drug resistance of bacteria, and the drug resistance of bacteria has increasingly become a serious problem affecting human health and life. In recent years, people have studied the mechanism of bacterial drug resistance, and found that the resistance of bacteria to β-lactams is related to the amount of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K9/08A61K9/12A61K9/14A61K9/20A61K31/43A61P31/04
Inventor 吴庆生马杰李平吴昌柱孙冬梅丁亚平
Owner TONGJI UNIV
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