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Compound micro-cream for acne treatment and preparation method thereof

A technology of microemulsion and acne, applied in the directions of ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve the problems of low cure rate and failure of microemulsion

Inactive Publication Date: 2006-12-20
中国人民解放军济南军区第四0一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The invention provides a compound acne micro-emulsion and its preparation method, which can solve the problems in the prior art that the cure rate is not high, and the micro-emulsion fails to become a dosage form for treating acne, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The formulation includes the following components,

[0064] (A) stearic acid 8%, cetyl alcohol 3%, glyceryl monostearate 3%, liquid paraffin 4%;

[0065] (B) 3% triethanolamine, 1% each of glycerin, propylene glycol, and 1,3-butanediol, 10% ethylparaben ethanol solution 1%;

[0066] (C) n-propanol 12%;

[0067] (D) Drugs: azithromycin 0.25%-0.75%, spironolactone 0.2%-0.4%, tretinoin 0.025%-0.05%;

[0068] The balance is purified water.

[0069] The method proceeds as follows,

[0070] ①. Take (A) and (B) components and heat them to 70-80°C in a water bath to keep warm;

[0071] ②. Take (D) component and dissolve it in (C) component, which can be dissolved together or separately;

[0072] ③.In the high shear emulsifier at 2000-6000r.min -1 Add (A) component to (B) component under stirring at a certain speed;

[0073] ④. Stir for 3-10 minutes, remove from the heat preservation water bath after emulsification is complete, and cool naturally;

[0074] ⑤. When the te...

Embodiment 2

[0077] The formulation includes the following components,

[0078] (A) 10% stearic acid, 2% cetyl alcohol, 2% glyceryl monostearate, 6% liquid paraffin;

[0079] (B) 4% triethanolamine, 5% propylene glycol, 10% ethylparaben ethanol solution 1%;

[0080] (C) n-butanol 10%;

[0081] (D) Drugs: azithromycin 0.25%-0.75%, spironolactone 0.2%-0.4%, tretinoin 0.025%-0.05%;

[0082] The balance is purified water.

[0083] ①. Take (A) and (B) components and heat them to 70-80°C in a water bath to keep warm;

[0084] ②. Take (D) component and dissolve it in (C) component, which can be dissolved together or separately;

[0085] ③.In the high shear emulsifier at 2000-6000r.min -1 Add (A) component to (B) component under stirring at a certain speed;

[0086] ④. Stir for 3-10 minutes, remove from the heat preservation water bath after emulsification is complete, and cool naturally;

[0087] ⑤. When the temperature of the paste drops to 60°C-50°C, add the (C) phase component, which ca...

Embodiment 3

[0090] The formulation includes the following components,

[0091] (A) stearic acid 9%, cetyl alcohol 3%, glyceryl monostearate 2.5%, liquid paraffin 4%;

[0092] (B) 4% triethanolamine, 2% each of 1,3-butanediol and glycerin, 10% ethylparaben ethanol solution 1%;

[0093] (C) n-propanol 5%, n-butanol 4%;

[0094] (D) Drugs: azithromycin 0.25%-0.75%, spironolactone 0.2%-0.4%, tretinoin 0.025%-0.05%;

[0095] The balance is purified water.

[0096] The method proceeds as follows,

[0097] ①. Take (A) and (B) components and heat them to 70-80°C in a water bath to keep warm;

[0098] ②. Take (D) component and dissolve it in (C) component, which can be dissolved together or separately;

[0099] ③.In the high shear emulsifier at 2000-6000r.min -1 Add (A) component to (B) component under stirring at a certain speed;

[0100] ④. Stir for 3-10 minutes, remove from the heat preservation water bath after emulsification is complete, and cool naturally;

[0101] ⑤. When the temper...

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PUM

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Abstract

Disclosed is a compound microemulsion cream for treating acne which comprises the following constituents (by weight ratio): (1) stearic acid 8-10%, cetyl alcohol 2-4%, glyceryl monostearate 2-3%, fluid wax 2-8%, (2) triethanolamine 3-5%, 2-6% of at least one selected from glycerin, propylene glycol, 1,3-butylene glycol, 10% of ethyl-p-hydroxybenzoate alcoholic solution 1%, (3) 8-12% of at least one of n-propanol, n-butanol and n-pentanol, (4) medicaments including Azithromycin 0.25-0.75%, spironolactone 0.2-0.4%, vitamine-A acid 0.025-0.05%, and balancing purified water.

Description

technical field [0001] The invention relates to medicines, in particular to medicines for treating acne and a preparation method. Background technique [0002] There are four main causes of acne formation: [0003] (1) excessive secretion of pilosebaceous glands, resulting in a large amount of cortical formation; [0004] (2) hyperkeratosis of sebaceous gland secretory duct cells; [0005] (3) Invasion and massive reproduction of Propionibacterium acnes in the sebaceous gland secretion duct; [0006] (4) The inflammatory response of the patient itself. [0007] After acne forms, roughly be divided into three grades according to the situation of skin lesion: mild, moderate and severe acne. [0008] Most of the compound preparations for the treatment of acne currently start from the second and third aspects of the cause of the disease, and select the first and second types of drugs with different pharmacological effects and have synergistic and complementary effects for th...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/14A61K47/44A61K31/7052A61P17/10A61K31/19A61K47/12A61K47/10A61K47/06
Inventor 王菊荣宋茹
Owner 中国人民解放军济南军区第四0一医院
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