Method for preparing Chinese medicine extract and quality control method

A technology for extracts and traditional Chinese medicines, applied in the field of preparation of traditional Chinese medicine extracts, can solve the problems of pollution of organic reagents, high cost of industrial-scale production, difficult reuse of resins, etc., and achieves the effect of simple and easy method and saving production costs.

Inactive Publication Date: 2007-01-24
NANJING TIANYUAN PEPTIDE PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both the n-butanol extraction method and the resin adsorption method have the disadvantages of high industrial scale production cost, contamination of organic reagents and difficulty in reusing the resin, which hinder the widespread use of Aralia aralia in clinical practice

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of Liaodong Aralia Soft Capsules

[0030] Take 15kg of Liaodong Aralia, add 50% ethanol and reflux 4 times, each time for 4 hours, combine the ethanol solution, adjust the alcohol concentration to 85%, filter, and recover the ethanol from the filtrate under reduced pressure and concentrate it to a relative density of 1.10-1.15 ( 60°C), add 0.5mol / L sulfuric acid to reflux for hydrolysis for 5 hours, evaporate ethanol, add 1mol / L NaoH to adjust the pH value to 7, filter, discard the filtrate, dry the precipitate, grind it into fine powder, add 1.2 times of Vegetable oil and beeswax mixture, compressed into 3000 soft capsules.

[0031] This product is a capsule, the contents are brown, slightly fragrant, bitter and astringent.

Embodiment 2

[0033] Preparation of Aralia longya pellets

[0034] Take 15kg of Aralia medicinal material, add 1% calcium carbonate, add water to decoct and extract 3 times, each time for 3 hours, combine the extracted water, filter, add ethanol to the filtrate to make the alcohol content reach 65%, let it stand, and filter , the filtrate recovered ethanol under reduced pressure and concentrated to a relative density of 1.15-1.18 (60°C), added 1mol / L sulfuric acid to reflux for hydrolysis for 7 hours, evaporated the ethanol, added 1mol / L NaoH to adjust the pH value to 7, filtered, and discarded the filtrate. Mix the precipitate with magnesium oxide, wash the mixture twice with 2 mol equivalent ammonia test solution, discard it, extract the mixture three times with 95% ethanol, combine the extracts, recover the ethanol to a thick paste, dry under reduced pressure, and prepare pellets.

Embodiment 3

[0036] Preparation of Liaodong Aralia Injection

[0037] Take Liaodong Aralia, add 40% ethanol and 10 times the amount of reflux 4 times, each time for 4 hours, combine the ethanol solution, adjust the alcohol concentration to 85%, filter, and recover the ethanol from the filtrate under reduced pressure and concentrate to a relative density of 1.10-1.15 (60 ℃), add 0.5mol / L sulfuric acid to reflux for hydrolysis for 8 hours, evaporate ethanol, add 1mol / L NaoH to adjust the pH value to 7, filter, discard the filtrate, mix the precipitate with magnesium oxide, wash with 5mol equivalent ammonia test solution The mixture was discarded twice, extracted three times with 90% ethanol, the extracts were combined, and the ethanol was recovered to a thick paste, dried under reduced pressure, diluted with an appropriate amount of water for injection from the dry extract, and ultrafiltered with a vacuum fiber to obtain the product.

[0038] This product is injection, the content is light y...

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Abstract

The present invention discloses the preparation process of Chinese medicine Chinese aralia extract, and is especially preparation process of Chinese aralia total sapogenin in Chinese medicine preparation technology. Chinese aralia total saponin is first obtained through water extraction or alcohol extraction, and then hydrolyzed and alcohol washed to separate out Chinese aralia total sapogenin. Compared with available resin separation process, the preparation process of the present invention is simple and feasible and can obtain extract with Chinese aralia total sapogenin content as high as 50 %. The present invention also discloses quality control method for the extract.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract, which belongs to the field of traditional Chinese medicine. Background technique [0002] Aralia elata (Miq) Seem, Aralia chinensis L. or Aralia decaisneana Hance, Aralia elata (Miq) Seem, Aralia elata (Miq) Seem, Aralia decaisneana Hance of the family Araliaceae, contain a variety of Aralia saponins. Saponins are hydrolyzed to obtain saponins, and the research results show that aralia saponins have obvious adaptogenic effects, and have many physiological activities such as strengthening the heart, lowering blood pressure, lowering blood sugar, lowering lipids, and protecting the liver. There are many documents on the method of extracting total saponins from Aralia medicinal materials, but these documents only stop at the extraction or refining of total saponins from Aralia, and the total saponins will be rehydrolyzed to obtain saponins during practical application...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61K36/25G01N30/02G01N33/15
Inventor 高淑英
Owner NANJING TIANYUAN PEPTIDE PHARMA TECH CO LTD
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