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Oral liquor contg. citalopram hydrobromide and its prepn. method

A technology of citalopram hydrobromide oral liquid and citalopram hydrobromide, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery and other directions, can solve problems such as lack of affinity or affinity, and achieve the effect Stable, small side effects, good taste effect

Inactive Publication Date: 2007-02-14
SHANGHAI CHANGCHENG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Citalopram is highly selective for the inhibition of serotonin reuptake, while for 5-HT1A, 5-HT2A receptors, dopamine D1, D2 receptors, adrenergic receptors, histamine H1 receptors, γ- No or very low affinity for GABA receptors, M-cholinergic receptors, and benzodiazepine receptors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Citalopram Hydrobromide 2g

[0026] Glycerin, Sorbitol 200g

[0027] Methylparaben 3g

[0028] Orange essence 0.1g

[0029] water 796g

[0030] Take an appropriate amount of water, heat to boiling, add 3g of preservative methylparaben to dissolve, let it cool, take 100g of sweetener and plasticizer glycerin, mix well, add 2g of main ingredient, stir to dissolve, then add sweetness Agent, plasticizer sorbitol 100g and orange flavor fragrance 100mg, solvent 796g, if necessary, use 0.1mol / L hydrochloric acid solution or 0.1mol / L sodium hydroxide solution to adjust the pH value to 5±1. Filtrate through a micro-air filter membrane, check the pH and content, and fill the filtrate after passing the test, and seal it with a gland to obtain the product.

Embodiment 2

[0032] Citalopram Hydrobromide 2g

[0033] Glycerin, Sorbitol 160g

[0034] Propylparaben 2g

[0035] Strawberry essence 0.1g

[0036] water 836g

[0037] Take an appropriate amount of water, heat to boiling, add 2g of preservative propylparaben to dissolve, let it cool, take 90g of sweetener and plasticizer glycerin, mix well, add 2g of main ingredient, stir to dissolve, then add sweetness Agent, plasticizer sorbitol 70g and strawberry essence fragrance 100mg, solubilizer water 836g, if necessary, use 0.1mol / L hydrochloric acid solution or 0.1mol / L sodium hydroxide solution to adjust the pH value to 5±1. Filtrate through a micro-air filter membrane, check the pH and content, and fill the filtrate after passing the test, and seal it with a gland to obtain the product.

Embodiment 3

[0039] Citalopram Hydrobromide 2g

[0040] Glycerin, Propylene Glycol 340g

[0041] Benzoic acid 1.5g

[0042] Orange essence 0.1g

[0043] water 656g

[0044] Take an appropriate amount of water, heat it to boiling, add 1.5g of preservative benzoic acid to dissolve, let it cool, take sweetener, plasticizer glycerin 140g, mix well, add 2g of main ingredient, stir to dissolve, then add sweetener, 200g of plasticizer propylene glycol and 100mg of orange essence fragrance, 656g of solubilizer, if necessary, use 0.1mol / L hydrochloric acid solution or 0.1mol / L sodium hydroxide solution to adjust the pH value to 5±1. Filtrate through a micro-air filter membrane, check the pH and content, and fill the filtrate after passing the test, and seal it with a gland to obtain the product.

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PUM

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Abstract

An oral liquid of citalopram hydrobromate is proportionally prepared from citalopram hydrobromate, sweetening agent, plasticizer, antiseptic, aromatic and solvent. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of preparation of pharmaceutical preparations, in particular to a citalopram hydrobromide oral liquid and a preparation method thereof. Background technique [0002] Citalopram Hydrobromide Oral Solution is mainly used for the treatment of endogenous and non-endogenous depression. Hydrocodone is a selective serotonin reuptake inhibitor (SSRI). It can enhance the synaptic transmission of serotonergic nerve and produce antidepressant effect. Its antidepressant effect is generally established within 2-4 weeks. Citalopram is highly selective for the inhibition of serotonin reuptake, while for 5-HT1A, 5-HT2A receptors, dopamine D1, D2 receptors, adrenergic receptors, histamine H1 receptors, γ- GABA receptors, M-cholinergic receptors, and benzodiazepine receptors have no or very low affinity. Antagonism of M-cholinergic receptors, histamine receptors, and adrenergic receptors is thought to be associated with anticholine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/343A61P25/24
Inventor 王苏南张苏闽董佳丽王显樑徐军军
Owner SHANGHAI CHANGCHENG PHARMA