Traditional Chinese medicinal formulation for treating cardiovascular and cerebrovascular disease

A technology of cardiovascular and cerebrovascular diseases and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine compositions for the treatment of cardiovascular and cerebrovascular diseases. It can solve the problems of being unable to take care of oneself, the burden of relatives and society, and achieve the effects of quality control, easy industrialization, and multiple benefits.

Inactive Publication Date: 2007-02-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The percentage of deaths due to cardiovascular and cerebrovascular diseases in the total death population in my country has risen from 12.07% in 1957 to 42.6% in 2001, and 2 million people died of cardiovasc

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Preparation of Danshensu extract: take Danshen decoction pieces, add water 5 times the weight of the crude drug, add 0.4% aqueous sodium bicarbonate solution to adjust the pH to 8, reflux extraction for 2 hours, and separate the extract; add 5 times the weight of the crude drug to the residue amount of water, reflux extraction for 2 hours, separate the extract, combine the two extracts, and filter; add 1.5% hydrochloric acid to the filtrate to adjust the pH of the solution to 2, filter or centrifuge, and concentrate the supernatant or filtrate under reduced pressure to a density of 1.08 (55-60°C); add 95% ethanol to the concentrated solution to make the alcohol concentration of the solution 50%, let it stand for 18 hours, filter, and concentrate the filtrate under reduced pressure until there is no alcohol smell; AB-8 type large Pore ​​resin (produced by Tianjin Nankai University Resin Factory) column, first wash away with water of 2 times the column volume, discard, the...

Embodiment 2

[0104] Preparation of Danshensu extract: take Danshen decoction pieces, crush them, add water 5 times the weight of the crude drug, add 0.35% sodium carbonate to adjust the pH to 9, extract by ultrasonic for 30 minutes, separate the extract; the residue is 5 times the weight of the crude drug amount of water, ultrasonic extraction for 20 minutes, separate the extract, combine the two extracts, and filter; add 2% acetic acid to the filtrate to adjust the pH of the solution to 2, filter or centrifuge, and concentrate the supernatant or filtrate under reduced pressure to a density of 1.06 (55-60°C); add 95% ethanol to the concentrated solution to make the alcohol concentration of the solution 40%, let it stand for 18 hours, filter, and concentrate the filtrate under reduced pressure until it has no alcohol smell; put D101 macroporous resin on the concentrated solution (produced by Resin Factory of Nankai University, Tianjin) column, wash off with water of 2 times column volume fir...

Embodiment 3

[0108] Preparation of Danshensu extract: take Danshen decoction pieces, crush them, add water 5 times the weight of the crude drug, add 0.35% sodium carbonate to adjust the pH value to 9, reflux extraction for 2 hours, separate the extract; the residue is 5 times the weight of the crude drug amount of water, reflux extraction for 1.5 hours, separate the extract, combine the two extracts, and filter; add 1% hydrochloric acid to the filtrate to adjust the pH of the solution to 2, filter or centrifuge, and concentrate the supernatant or filtrate under reduced pressure to a density of 1.06 (55-60°C); add 95% ethanol to the concentrated solution to make the alcohol concentration of the solution 65%, let it stand for 18 hours, filter, and concentrate the filtrate under reduced pressure to no alcohol smell; polyamide (Qingdao Haiyang Chemical Plant) column, collect the eluate; the eluate is then loaded on the ZTC type macroporous resin (produced by Tianjin Nankai University Resin Fact...

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Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, which comprises 5.0-80.0% of danshensu extract containing danshensu 50-98%, 15.0-93.0% of pseudo-ginseng extract containing total notoginsen triterpenes 70-98%, and natural borneol or rosewood oil 2.0-15.0%. The composition has evident functions in resisting cerebral ischemia and myocardial ischemia, the curative effect is better than the application of single extract of red sage root or notoginseng, thus providing a more effective and more convenient Chinese medicinal composition and preparation clinically.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural areas or cities. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth among the causes of death in my country, and rose to second and third respectively after 1975. Cardiovascular and cerebrovascular diseases accounted for the first place among all causes of death. The percentage of deaths due to cardiovascular and cerebrovascular diseases in the total death population in my country has risen from 12.07% in 1957 to 42.6% in 2001, and 2 million people died of cardiovascular and cerebrovascular diseases every year, and some patients survived ...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/14A61K9/20A61P9/00A61K31/045
Inventor 叶正良李旭张文生魏峰李德坤
Owner TIANJIN TASLY PHARMA CO LTD
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