Terbinafine nano milk-like liquid antifungal medicine and its preparation

Abstract

The invention discloses a terbinafine nanometer antifungal which is prepared by terbinafine, oil, surfactant, water according to the following method: First, the said raw materials are unloaded and weighed and reserved, then surfactants and oil is blended and mixed; terbinafine is added into cosurfactant and completely dissolved; the solution with terbinafine dissolved in it is added to the homogeneous mixed surfactant and oil, stirring uniform, finally, distilled water is slowly added dropwise, dropwising and stirring until the stable, homogeneous, transparent terbinafine nanometer antifungal is obtained. The drug with small particles, small viscosity, good fluidity and good nature stability, can reach through the skin and get into the blood circulation, inhibit squalene cycloxygenase, so as to treat the dermatophyte infection and many deep mycotic infection with a drastic therapeutic effect, and what is more the preparation of the invented products is simple, low energy consumption and without special equipment the drug can be mass produced.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of an antifungal drug terbinafine, in particular to a terbinafine nanoemulsion antifungal drug and a preparation method thereof. Background technique [0002] Terbinafine is an allylamine broad-spectrum antifungal drug that can be taken orally or externally. )-N-methyl-1-naphthalene-methylamine, white or off-white crystalline powder, slightly soluble in water. Metabolized in the liver, distribution phase t 1 / 2 About 1.1 hours to eliminate phase t 1 / 2 About 16 hours. It is suitable for the treatment of tinea corporis, jock itch, tinea pedis, tinea unguium and skin candida infection caused by superficial fungi. In recent years, it has been found that it also has a strong therapeutic effect on many deep fungal infections. It selectively inhibits the squalene epoxidase of fungi, causing the accumulation of squalene in fungal cells, the lack of ergosterol, and the fat deposi...

AI Technical Summary

Problems solved by technology

For example: its water solubility is poor, and the drug concentration of the dosage form currently used in clinical practice is generally low; it is mainly metabolized in the liver, and the risk of taking it is relatively high for those with liver and kidney insufficiency; the common adverse reactions are mainly nausea, diarrhea, anorexia, mild Abdominal pain, loss of taste, and skin reactions (rash, hives, etc.)