Terbinafine nano milk-like liquid antifungal medicine and its preparation

The technology of an antifungal drug, terbinafine, is applied in the field of medicine, which can solve the problems of high risk of taking, poor water solubility, and low concentration, and achieve the effect of simple preparation method, low surface tension, and uniform distribution

Inactive Publication Date: 2007-03-14
NORTHWEST A & F UNIV
0 Cites 7 Cited by

AI-Extracted Technical Summary

Problems solved by technology

For example: its water solubility is poor, and the drug concentration of the dosage form currently used in clinical practice is generally low; it is mainly metabolized in the liver, and the risk of taking it ...
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Abstract

The invention discloses a terbinafine nanometer antifungal which is prepared by terbinafine, oil, surfactant, water according to the following method: First, the said raw materials are unloaded and weighed and reserved, then surfactants and oil is blended and mixed; terbinafine is added into cosurfactant and completely dissolved; the solution with terbinafine dissolved in it is added to the homogeneous mixed surfactant and oil, stirring uniform, finally, distilled water is slowly added dropwise, dropwising and stirring until the stable, homogeneous, transparent terbinafine nanometer antifungal is obtained. The drug with small particles, small viscosity, good fluidity and good nature stability, can reach through the skin and get into the blood circulation, inhibit squalene cycloxygenase, so as to treat the dermatophyte infection and many deep mycotic infection with a drastic therapeutic effect, and what is more the preparation of the invented products is simple, low energy consumption and without special equipment the drug can be mass produced.

Application Domain

Organic active ingredientsAntimycotics +1

Technology Topic

ChemistryDermatophyte +15

Examples

  • Experimental program(6)
  • Effect test(2)

Example Embodiment

[0059] Example 1
[0060] Accurately weigh 4.5 g of polyoxyethylene ether (40) hydrogenated castor oil, 1.0 g of ethanol (where 0.02 g of terbinafine is dissolved), and 0.5 g of olive oil, stir and mix at 20°C, and then slowly add to it Distilled water, add and stir, the viscosity of the system is small at the beginning, as the amount of water increases, the system becomes viscous, continue to add distilled water dropwise and keep stirring, when the system suddenly becomes thinner, the O/W type is produced at this time. color and transparent terbinafine nanoemulsion, weighing 10.0 g.

Example Embodiment

[0061] Example 2
[0062] Accurately weigh 4.5 g of castor oil polyoxyethylene ether, 1.0 g of ethanol (where 0.06 g of terbinafine is dissolved), and 0.5 g of isooctyl ester, stir and mix at 22 ° C, and then slowly add distilled water to it, while Add and stir, the viscosity of the system is small at the beginning, and as the amount of water increases, the system becomes viscous. Continue to add distilled water dropwise and stir continuously. When the system suddenly becomes thinner, the O/W type colorless and transparent characteristic is produced. Binafine nanoemulsion, weighed 10.0 g.

Example Embodiment

[0063] Example 3
[0064] Accurately weigh 4.5 g of polyoxyethylene ether (40) hydrogenated castor oil, 1.0 g of ethanol (where 0.10 g of terbinafine is dissolved), and 0.5 g of castor oil, stir and mix at 24°C, and then slowly add to it Distilled water, add and stir, the viscosity of the system is small at the beginning, as the amount of water increases, the system becomes viscous, continue to add distilled water dropwise and keep stirring, when the system suddenly becomes thinner, the O/W type is produced at this time. color and transparent terbinafine nanoemulsion, weighing 10.0 g.

PUM

PropertyMeasurementUnit
Particle size10.0 ~ 100.0nm

Description & Claims & Application Information

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