Terbinafine nano milk-like liquid antifungal medicine and its preparation
The technology of an antifungal drug, terbinafine, is applied in the field of medicine, which can solve the problems of high risk of taking, poor water solubility, and low concentration, and achieve the effect of simple preparation method, low surface tension, and uniform distribution
Inactive Publication Date: 2007-03-14
NORTHWEST A & F UNIV
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Abstract
The invention discloses a terbinafine nanometer antifungal which is prepared by terbinafine, oil, surfactant, water according to the following method: First, the said raw materials are unloaded and weighed and reserved, then surfactants and oil is blended and mixed; terbinafine is added into cosurfactant and completely dissolved; the solution with terbinafine dissolved in it is added to the homogeneous mixed surfactant and oil, stirring uniform, finally, distilled water is slowly added dropwise, dropwising and stirring until the stable, homogeneous, transparent terbinafine nanometer antifungal is obtained. The drug with small particles, small viscosity, good fluidity and good nature stability, can reach through the skin and get into the blood circulation, inhibit squalene cycloxygenase, so as to treat the dermatophyte infection and many deep mycotic infection with a drastic therapeutic effect, and what is more the preparation of the invented products is simple, low energy consumption and without special equipment the drug can be mass produced.
Application Domain
Organic active ingredientsAntimycotics +1
Technology Topic
ChemistryDermatophyte +15
Examples
- Experimental program(6)
- Effect test(2)
Example Embodiment
Example Embodiment
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PUM
Property | Measurement | Unit |
Particle size | 10.0 ~ 100.0 | nm |
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