Ginkgo leaf extract and barrenwort extract composition

A technology of extract and composition of Epimedium is applied in the field of medicine to achieve the effects of prolonging the time of thrombosis, lowering blood pressure and inhibiting the formation of thrombosis

Inactive Publication Date: 2007-03-28
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, using the interaction of Ginkgo biloba extract and Epimedium extract to make compatible prescriptions to prepare drugs for treating cardiovascular and cerebrovascular diseases has not yet been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0192] Example 1 Preparation, Identification and Content Determination of Ginkgo Leaf Extract

[0193] Preparation of Ginkgo biloba extract

[0194] Take 5kg of ginkgo leaves, crush them, add 70% ethanol and extract twice at 60°C, add 15 times the amount of alcohol each time, soak for 2 hours under stirring, combine the extracts, filter, and recover the ethanol from the filtrate until the relative density is 1.03~ 1.09 (50°C), add 4 times the amount of water, stir well, refrigerate overnight at 1-4°C, filter, put the filtrate on the column, wash with 3-4 times the volume of water, 15% ethanol, and 70% ethanol, and collect 70% % ethanol solution, concentrated under reduced pressure, dried in vacuo, added 5 times the amount of ethanol to extract twice, 15 minutes each time, combined filtrate, concentrated under reduced pressure, dried in vacuo, added 8 times the amount of water to the extract, heated to boiling, slightly Boil for 5 minutes, place at room temperature, refriger...

Embodiment 2

[0217] Example 2 Preparation, Identification and Content Determination of Epimedium Extract (1)

[0218] Preparation of Epimedium Extract

[0219] Take 1kg of Epimedium, cut into small pieces, add water to decoct twice, each time for 1.5 hours, each time add water to 10L. Combine the decoctions, put them in cold storage overnight, filter, concentrate the filtrate to a concentrated solution with a relative density of 1.08 to 1.10, add it to the treated polyamide resin column, wash it with 3 to 4 times the column volume of water, and then wash it with 2 Rinse with 20% ethanol for ~3 times the column volume, discard the washing solution, and then elute with 95% ethanol for 4 to 5 times the column volume, collect the eluate, recover the ethanol, and spray dry to obtain the product.

[0220] Three batches of Epimedium extracts were prepared respectively, and the yields are shown in Table 2-1.

[0221] Identification of Epimedium Extract

[0222]Take 0.1g of Epimedium extract, ...

Embodiment 3

[0233] Example 3 Preparation, Identification and Content Determination of Epimedium Extract (2)

[0234] Preparation of Epimedium Extract

[0235] Take 5kg of Epimedium medicinal material, crush it into medium powder, add 12 times the amount of 70% ethanol, soak for 12 hours, filter, and use the filtrate for later use; add 70% ethanol to the dregs and heat and extract three times, each time for 1.5 hours, filter, and combine the filtrate , the filtrate was concentrated under reduced pressure to 1000ml, put on the treated polyamide column, first eluted with 15L of distilled water, then eluted with 3L of 15% ethanol, and finally eluted with 20L of 70% ethanol, collected the 70% ethanol eluate, Recover ethanol under reduced pressure and dry it in vacuum to obtain the product.

[0236] Three batches of Epimedium extracts were prepared respectively, and the yields are shown in Table 2-3.

[0237] Identification of Epimedium Extract

[0238] According to the identification meth...

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PUM

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Abstract

The present invention discloses a new medicine composition, its preparation method and application. It includes ginkgo leaf extract and epimedium extract, their weight mixing ratio is 1:0.16-100. It can be made into injection preparation and oral preparation, and mainly is used for preparing the medicine capable of curing angiocardiopathy and cerebrovascular diseases.

Description

1. Technical field [0001] The invention relates to a new pharmaceutical composition, its application in the preparation of drugs for treating cardiovascular and cerebrovascular diseases, and a preparation containing the pharmaceutical composition, belonging to the technical field of medicine. 2. Background technology [0002] In medicine, cardiovascular and cerebrovascular diseases refer to diseases of heart ischemia or hemorrhage caused by hardening of the heart and arteries, including coronary heart disease, angina pectoris, hypertension, arrhythmia, myocardial infarction, cerebral infarction, etc. Cardiovascular and cerebrovascular diseases have always been known as the number one killer threatening human health. Hypertension, hyperlipidemia, coronary heart disease, and diabetes have become "the plague of the times." In recent years, the incidence of cardiovascular and cerebrovascular diseases has been increasing year by year, especially the age of onset and death is beco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/296A61P9/06A61P9/10A61P9/12A61P7/02A61P3/06
Inventor 蔡军
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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