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Method for preparing full-trans beta-carrotin

A carotene and all-trans technology, applied in the direction of organic chemistry, can solve the problems of large solvent consumption and low transposition yield, and achieve the effect of less solvent consumption, high reaction yield and large processing capacity

Active Publication Date: 2007-03-28
ZHEJIANG UNIV +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method selects water as the transposition solvent, organic solvents such as acetone are also used in the follow-up treatment, and the amount of solvent is large in addition, so the transposition yield is not high.

Method used

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  • Method for preparing full-trans beta-carrotin

Examples

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Comparison scheme
Effect test

Embodiment 1

[0016] In a 1000ml three-necked flask, add 100g of Dunaliella β-carotene extract containing 48% cis-isomer and 1000g of glycerol, control the reaction temperature to be 130°C, and react in the dark for 3 hours under nitrogen protection, then cool to 70°C °C, the reaction was continued for 12 hours. After the reaction, the mixture was filtered while hot, washed with water, and dried to obtain 98 g of β-carotene containing 99% all-trans isomer.

Embodiment 2

[0018] Add 500g of synthetic β-carotene containing 67% cis-isomer and 500g of propylene glycol in a 1000ml three-necked flask, control the reaction temperature to 160°C, react under nitrogen protection and avoid light for 5 hours, then cool down to 100°C, and continue the reaction for 25 Hour. After the reaction, the mixture was filtered while hot, washed with water, and dried to obtain 492 g of β-carotene containing 98% all-trans isomer.

Embodiment 3

[0020] In a 1000ml three-necked flask, add 200g of synthetic β-carotene containing 26% cis-isomer and 800g of glycerol monoacetate, control the reaction temperature to be 120°C, react in the dark for 6 hours under nitrogen protection, then cool down to 80°C, The reaction was continued for 22 hours. After the reaction, the mixed solution was filtered while hot, washed with water and dried to obtain 195 g of β-carotene containing 98% all-trans isomer.

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Abstract

The invention discloses a total reversal beta-carotene preparing method, mixing beta-carotene and high-boiling point, low-toxicity polar solvent at 70-160 deg.C in the mass ratio of 1 to (1-10), reacting in protective nitrogen gas for 10-30 h, filtering and water-washing and drying to make it. And the invention has advantages of: 1) using low-toxicity solvent as reacting medium, safe and environmental-protection and applied to transposition of natural beta-carotene and synthetic beta-carotene in the courses of preparing drugs, food, feeds, and other preparation products at various levels; 2) high reaction temperature, fast transposition and basically having no by-products; 3) the selected solvent basically has no solubility to beta-carotene, and the reaction yield is high; 4) large beta-carotene processing quality of the selected solvent and less solvent utilization.

Description

technical field [0001] The invention relates to a preparation method of all-trans β-carotene. Background technique [0002] β-Carotene is a typical representative of the carotenoid family. It is not only an important source of vitamin A in the body, but also has important physiological functions for the human body. It can prevent, delay and treat certain diseases , especially cancer, but also can improve the immune function of the body. Its molecular formula is C 40 h 56 , the molecular weight is 536.88, and its molecular structure is shown in the figure. [0003] [0004] Because the β-carotene molecule contains a long conjugated double bond chromophore, it has the property of being absorbed by light. It is a dark red to dark red shiny oblique hexahedral or plate crystal crystal or crystalline powder, dilute The solution is orange-yellow to yellow, orange when the concentration increases, and slightly red due to the polarity of the solution. Insoluble in water, meth...

Claims

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Application Information

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IPC IPC(8): C07C403/24
Inventor 仇丹陈志荣李建东罗素红吴建华
Owner ZHEJIANG UNIV
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