Preparation method of mannose

A technology of mannose and mannose, which is applied in the field of mannose preparation, can solve the problems of increasing the complexity of operation, easily remaining organic solvents, increasing energy consumption costs, etc., achieving less separation column consumption, realizing the separation of ternary components, The effect of simplifying the production process

Inactive Publication Date: 2012-12-05
白心亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method also needs to go through multiple concentration steps, which increases energy consumption costs; the method of ethanol crystallization to obtain the final product lasts 4.5-6 hours, which not only takes a long time, but also tends to leave organic solvents, and at the same time, it is necessary to strictly control the addition time of seed crystals and stirring speed, increasing the complexity of the operation

Method used

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  • Preparation method of mannose
  • Preparation method of mannose
  • Preparation method of mannose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Dilute 5kg of crystalline glucose with purified water to a solid mass percentage concentration of 50wt.%, add 15g of catalyst ammonium molybdate, and carry out epimerization under the conditions of 0.2MPa and 110 ° C for 2h, and the obtained isomerized mixed solution contains manna The mass percentage concentration of sugar was 15.2 wt.%. After decolorizing, desalting and refining the above-mentioned heterogeneous mixed solution, it enters into a six-column sequential simulated moving bed 1 (the filler is calcium-type cationic resin) for separation and purification to obtain a mannose-rich component A and a glucose-rich component B, The purity of mannose in component A was 88.3%. Then, component A enters the six-column sequential simulated moving bed 2 (the filler is calcium molecular sieve) for secondary separation to obtain mannose-rich component C and glucose-rich component D. The purity of mannose in component C is obtained. is 99.5%. Component B is filtered throu...

Embodiment 2

[0038] Dilute 5kg of crystalline glucose with purified water to a solid mass percentage concentration of 50wt.%, add 15g of catalyst ammonium molybdate, and carry out epimerization under the conditions of 0.15MPa and 105°C for 2h, and the obtained isomerized mixed solution contains manna The sugar mass percentage concentration was 14.5 wt.%. After decolorizing, desalting and refining the obtained isomerized mixed solution, it enters into a six-column sequential simulated moving bed 1 (the filler is calcium-type cation resin) for separation and purification to obtain a mannose-rich component A and a glucose-rich component B, The purity of mannose in component A was 87.2%. Then, component A enters the six-column sequential simulated moving bed 2 (the filler is calcium molecular sieve) for secondary separation to obtain mannose-rich component C and glucose-rich component D. The purity of mannose in component C is obtained. was 99.2%. Component B is filtered through the membrane...

Embodiment 3

[0040]Dilute 5kg of crystalline glucose with purified water to a solid mass percentage concentration of 50wt.%, add 15g of catalyst ammonium molybdate, and carry out epimerization for 2h under the conditions of normal pressure and 100 ℃, and the obtained isomerized mixed solution contains manna The sugar mass percentage concentration was 13.6 wt.%. After decolorizing, desalting and refining the obtained isomerized mixed solution, it enters into a six-column sequential simulated moving bed 1 (the filler is calcium-type cation resin) for separation and purification to obtain a mannose-rich component A and a glucose-rich component B, The purity of mannose in component A was 86.2%. Then, component A enters the six-column sequential simulated moving bed 2 (the filler is calcium molecular sieve) for secondary separation to obtain mannose-rich component C and glucose-rich component D. The purity of mannose in component C is obtained. was 99.1%. Component B is filtered through the m...

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Abstract

The invention discloses a preparation method of D-mannose, which comprises the following steps that glucose is epimerized under a normal pressure or pressurized condition by using ammonium molybdate as catalyst to obtain mixed solution of glucose and mannose; the mixed solution is discolored, desalted and refined and then enters a simulated moving bed 1 for separation and purification to obtain a component A rich in mannose and a component B rich in glucose; the component A enters a simulated moving bed 2 for separation to obtain a component C rich in mannose and a component D rich in glucose; the component B is filtered through a membrane and then enters the step of epimerization; the component D is filtered through a membrane and then enters the simulated moving bed 1 for cyclic separation; and the component C is centrifugally spray-dried to obtain D-mannose finished products. The preparation method of the D-mannose has the advantages of simple steps and easiness in operation. The purity of the D-mannose finished products prepared by adopting the method reaches more than 99 percent and the total yield reaches 53-60.4 percent.

Description

technical field [0001] The present invention relates to a preparation method of mannose. Background technique [0002] D-mannose (D-mannose) is a six-carbon sugar, is an isomer with glucose, easily soluble in water, insoluble in ethanol, insoluble in ether, sweet in taste, slightly bitter aftertaste. It is rarely found in the free state in nature, and mostly exists in the form of mannan; it is often used as a sweetener for food and beverages, and is also used in the field of medicine for the adjuvant treatment of diseases such as diabetes, obesity, constipation and high cholesterol. . In recent years, mannose also has the effects of inhibiting tumor growth, preventing bacterial and viral infections, alleviating the symptoms of rheumatoid arthritis, and inhibiting the occurrence of inflammation during wound healing. [0003] CN101851689A discloses a preparation method of mannose, which uses glucose as raw material, obtains a mixture of glucose and mannose through epimerizat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/02C07H1/00C07H1/06
Inventor 廖小雪赵永强孙立贾洪涛
Owner 白心亮
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