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Traditional Chinese medicine gels for treating acute gout arthritis

A technology of acute gout and gel, which is applied in the field of traditional Chinese medicine, can solve clinical problems, iatrogenic diseases, and complicated treatment, and achieve good therapeutic effect, avoid first-pass effect, and high bioavailability

Active Publication Date: 2007-05-02
贵州苗仁堂制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although western medicine has used colchicine to reduce inflammation and relieve pain, allopurinol to inhibit the production of uric acid, propanesulfonic acid, etc. to promote the excretion of uric acid, etc., but the effect is not very satisfactory, coupled with serious side effects, which limit its clinical application to varying degrees
Especially colchicine, although it is a classic drug for the treatment of acute gouty arthritis, after it is taken orally, some drugs combine with gastrointestinal mucosal epithelial cells to cause gastrointestinal reactions, and the therapeutic dose is close to the dose of gastrointestinal toxic and side effects. Intravenous administration can inhibit the mitosis of systemic cells
Therefore, the systemic administration method has obvious toxic and side effects, easily causes new iatrogenic diseases, makes the treatment more complicated, and most patients are difficult to adhere to the treatment, which is quite difficult clinically.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take the following weight ratio of Chinese herbal medicine Arrowhead: Panax notoginseng = 1:1, grind the two medicinal materials into coarse powder, add 70% ethanol to extract, recover the solvent from the extract, concentrate to 1.05-1.08 or dry under reduced pressure. Add 10% 1,2-propanediol and 5% carbomer, adjust the pH to 6.0 with sodium hydroxide solution, stir evenly, and fill it to obtain the gel for skin.

Embodiment 2

[0024] Take the following weight ratio of Chinese herbal medicine Arrowhead: Panax notoginseng=1:4, grind the two medicinal materials into coarse powder, add 75% ethanol to extract, recover the solvent from the extract and concentrate to 1.05-1.08 or dry under reduced pressure. Add 8% 1,2-propanediol and 6% carbomer, adjust the pH to 6.0 with sodium hydroxide solution, stir evenly, and fill it to obtain the gel for skin.

Embodiment 3

[0026] Take Sanzhi mushroom: Panax notoginseng = 1:10, crush the two medicinal materials into coarse powder, add 70% ethanol to extract, recover the solvent from the extract and concentrate to 1.05-1.08 or dry under reduced pressure. Add 15% of 1,2-propanediol and 5% of carbomer, adjust the pH to 6.0 with sodium hydroxide solution, stir evenly, and fill to prepare the gel for skin.

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PUM

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Abstract

A Chinese medicine in the form of gel for treating acute gouty arthritis by exterior application is prepared from appendiculate cremastia pseudobulb, notoginseng and medicinal auxiliary.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine preparation for external use, in particular to a traditional Chinese medicine gel for treating acute gouty arthritis and a preparation method thereof. Background technique [0002] Gout is a disease caused by long-term purine metabolism disorder. The clinical features are hyperuricemia, recurrent acute arthritis, tophi deposition, chronic arthritis and joint deformity, renal parenchymal lesions and urate stone formation. According to relevant statistics, the incidence rate in developed countries is more than 0.3%, mainly concentrated in middle-aged and elderly people. In recent years, due to the general improvement of people's living standards and the increase in intake of animal protein and fat, the prevalence of gout in my country has been increasing year by year, approaching the incidence in developed countries. [0003] Gouty arthritis...

Claims

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Application Information

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IPC IPC(8): A61K36/39A61K36/258A61P19/06A61P19/02
Inventor 魏莉王志盛青周浩林洁
Owner 贵州苗仁堂制药有限责任公司
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