External preparation of Levocetirizine hydrochloric acid

A technology of levocetirizine hydrochloride and external preparations, which is applied in the field of pharmaceutical preparations, can solve the problems of unfavorable tissue distribution of levocetirizine hydrochloride, unsatisfactory administration mode, less blood flow distribution, etc. Allergy and anti-inflammatory effect, increase free drug concentration, good effect of transdermal absorption

Active Publication Date: 2007-05-09
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 3. Levocetirizine hydrochloride has rapid absorption in vivo, limited distribution and low metabolic rate;
However, the blood flow distribution of skin tissue is relatively small, which makes the tissue distribution of levocetirizine hydrochloride very unfavorable for its treatment of skin allergic diseases and dermatitis, and is applied to skin diseases through oral administration in large doses , it will inevitably bring some unexpected serious systemic adverse reactions, which is a very unsatisfactory way of administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Levocetirizine Hydrochloride Liniment

[0052] Levocetirizine Hydrochloride 20g

[0053] Ethanol 35ml

[0054] Propylene glycol 100ml

[0055] Add phosphate buffered saline (PBS) to 1000ml

[0056] Preparation Process:

[0057] Dissolve levocetirizine hydrochloride in an appropriate amount of phosphate buffered saline (PBS), add the prescribed amount of ethanol and propylene glycol, and then add phosphate buffered saline (PBS) to 1000ml.

Embodiment 2

[0059] Levocetirizine Hydrochloride Liniment

[0060] Levocetirizine Hydrochloride 10g

[0061] Ethanol 200ml

[0062] Propylene glycol 300ml

[0063] Add distilled water to 1000ml

[0064] Preparation Process:

[0065] Dissolve levocetirizine hydrochloride in an appropriate amount of distilled water first, add the prescribed amount of ethanol and propylene glycol, and then add distilled water to 1000ml.

[0066] The liniment prepared in embodiment 1 and embodiment 2 is packed in a specific container (sprayer or atomizer), and can be used as a spray.

Embodiment 3

[0068] Levocetirizine hydrochloride ointment

[0069] Levocetirizine Hydrochloride 8g

[0070] Carboxymethylcellulose 40g

[0071] Glycerin 400g

[0072] Lauryl Alcohol 15g

[0073] Ethylparaben 2g

[0074] Distilled water up to 1000g

[0075] Preparation Process:

[0076] Mix carboxymethyl cellulose and glycerin, then add an appropriate amount of hot distilled water, let it swell into a gel, then add an aqueous solution containing levocetirizine hydrochloride, lauryl alcohol, and ethylparaben, and add water to a sufficient amount That's it.

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PUM

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Abstract

An exterior-applied levocetirizine hydrochloride for preventing and treating the anaphylaxia and inflammation without untoward effect is disclosed.

Description

Technical field [0001] The invention belongs to the technology of pharmaceutical preparations. Background technique [0002] With the change of climate and environment, various harmful gases, dust and other pollution sources emerge in large numbers, which become allergens that cause people to have various allergic reactions. Seasonal changes, field work, pollen allergies, inhalation of harmful gases and dust particles, etc., have caused more and more people to suffer from various types of allergic diseases, allergic rhinitis, urticaria, skin redness, itching, redness Asthma caused by spots and allergens is very common. Therefore, it is very important to develop drugs for the treatment of allergic diseases. [0003] At present, the second-generation antihistamine drugs are mainly used in the clinical treatment of allergic diseases, among which cetirizine has the strongest drug activity, has better anti-inflammatory and anti-allergic effects, and has the highest bioavailabil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61K9/00A61K9/06A61P37/08A61P17/00
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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