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Method for preparing magnetic macromolecular microsphere of crosslinking dialdehyde starch

A technology of polymer microspheres and dialdehyde starch, which is applied in the directions of non-active ingredients, such as medical preparations, pharmaceutical formulations, inorganic non-active ingredients, etc. , to achieve the effect of increased solid load and easy combination

Inactive Publication Date: 2007-05-16
GUILIN UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

[0005] However, looking at the current literature reports, most scholars have prepared starch magnetic microspheres. Since the microspheres only contain hydroxyl groups, when used in targeted preparations, drugs containing only amino groups are not easy to combine with hydroxyl groups, making the drugs difficult to immobilize. Carried on starch magnetic microspheres, in addition, drug carriers containing only hydroxyl groups are not easy to combine with proteases in the human body, so that the efficacy of such targeted agents is low
Therefore, the research on modified starch magnetic microspheres has attracted widespread attention, but has not been reported yet.

Method used

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Examples

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Embodiment

[0016] Weigh 3.0 g of tapioca starch and dissolve it in a certain amount of distilled water, add it to a three-necked flask, and add 50 mL of 0.5 mol / L ammonium iron (III) sulfate and ferrous sulfate respectively under stirring and heating in a water bath at 34 °C (II) Ammonium mixed solution; then quickly add 1mol / L sodium hydroxide solution until the solution is black and bright, set the stirring speed at 1200r / min, the temperature at 34°C, and continue the reaction for 30min.

[0017] After the reaction is over, move the flask containing the reaction solution into an ultrasonic cleaner and vibrate ultrasonically for about 20 minutes to disperse the starch magnetic microspheres. Add 3 mL of epichlorohydrin to the solution after ultrasonication, and react for 5 to 6 hours at a stirring speed of 1200r / min and a temperature of 60°C (heated in a water bath), so that the epichlorohydrin and the hydroxyl groups in the starch are formed. crosslinking reaction.

[0018] Wash the pr...

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Abstract

The invention relates to a method for preparing magnetic natural macromolecule micro ball as target drug carrier, wherein the invention modifies the amidon magnetic micro ball, prepares crosslink bi-aldehydes amidon magnetic micro ball, to convert more hydroxyl into aldehydes, to combine the -NH2 of drug; when the micro ball is used to target drug preparation, it can improve the carry amount, to combine the human protein enzyme at the ill part.

Description

technical field [0001] The invention relates to the field of functional polymer materials, in particular to a preparation method of magnetic natural polymer microspheres which can be used as targeted drug delivery carriers. Background technique [0002] The research on magnetic microspheres began in the late 1970s. Ugelstad successfully prepared monodisperse polystyrene magnetic microspheres with uniform size under gravity conditions. In the past two decades, the research on magnetic polymer microspheres has been very active, and has developed from the simplest polymer-wrapped magnetic material to various types of composition. Magnetic polymer microspheres generally have many excellent characteristics, such as small particle size, large surface area, easy adsorption, paramagnetism, uniform and stable dispersion in solution without an external magnetic field, and simple and rapid separation with a magnetic field; The characteristics of the ball can be endowed with a variety ...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/02C08B31/00
Inventor 王莉刘峥王丽娟
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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