Total coumarins extract from peucedanum praeruptorum dunn, and its preparing method and use

A technology of Baihuaqianhu and total coumarin, which is applied in the direction of testing pharmaceutical preparations, pharmaceutical combinations, pharmaceutical formulations, etc., can solve the problems of difficult quality control, slow action, etc., and achieves strong efficacy, small toxic and side effects, and safe range. big effect

Active Publication Date: 2007-06-13
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the main problem that exists at present is that it plays a role slowly, and the quality is difficult to control, etc., so the use of the drug is also subject to certain limitations.

Method used

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  • Total coumarins extract from peucedanum praeruptorum dunn, and its preparing method and use
  • Total coumarins extract from peucedanum praeruptorum dunn, and its preparing method and use
  • Total coumarins extract from peucedanum praeruptorum dunn, and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] A total coumarin extract of Peucedanum candidum, which contains 50% of sagerin by weight percentage;

[0144] Grind the root of Peucedanum baicalensis into coarse powder, heat reflux to extract 8 times the amount of 60% ethanol, filter, concentrate the filtrate to recover the ethanol until it has no alcohol smell, add distilled water to the obtained paste, mix it with 3 times the amount of ethyl acetate Extracted 3 times, recovered ethyl acetate, concentrated into a thick paste, added petroleum ether, ultrasonicated for 20 minutes and then stood still, precipitated, filtered, and washed with petroleum ether until light yellow.

Embodiment 2

[0146] A total coumarin extract of Peucedanum candidum, which contains 60% of sagerin by weight percentage;

[0147] Grind the root of Peucedanum baicalensis into coarse powder, heat reflux to extract 8 times the amount of 75% ethanol, filter, concentrate the filtrate to recover the ethanol until it has no alcohol smell, add distilled water to the obtained paste, mix it with 1 times the amount of ethyl acetate Extract 5 times, recover ethyl acetate, condense into a thick paste, add petroleum ether, let stand after ultrasonication for 20 minutes, precipitate precipitates, filter, and wash the precipitate with petroleum ether until light yellow.

Embodiment 3

[0149] A total coumarin extract of Peucedanum candidum, containing 75% of sagerin by weight percentage;

[0150] Grind the root of Peucedanum baicalensis into coarse powder, heat and reflux extraction with 10 times the amount of 95% ethanol, filter, concentrate the filtrate to recover the ethanol until it has no alcohol smell, add distilled water to the obtained paste, mix it with 1 times the amount of ethyl acetate Extracted 3 times, recovered ethyl acetate, concentrated into a thick paste, added petroleum ether, ultrasonicated for 20 minutes and then stood still, precipitated, filtered, and washed with petroleum ether until light yellow.

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Abstract

The present invention relates to a Chinese medicine extract, its preparation method and application. In the concrete, it relates to a peucedanum praeruptorum total coumarin extract, its preparation method and application in preparation of medicine for curing hypertension. Said peucedanum praeruptorum total coumarin extract is obtained by using Chinese medicinal material peucedanum praeruptorum through the processes of extraction and separation.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, its preparation method and its application, in particular to an extract of Peucedanum radix total coumarin, its preparation method, and its application in the preparation of medicines for treating hypertension. Background technique [0002] Hypertension is the chronic disease with the highest incidence rate in the world today, and it is also one of the diseases with the highest mortality and disability rates. In China, 120 people die from various cardiovascular and cerebrovascular diseases caused by high blood pressure every hour, and 600 people become disabled due to high blood pressure every hour. It seriously endangers human health and affects the quality of life. The clinical manifestations are headache, dizziness, dizziness, neck tension, tinnitus, vertigo, forgetfulness, insomnia, boredom, fatigue, numbness of limbs, palpitations, etc. It is also an important cause of limb hemipleg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61K31/37A61P9/12G01N30/02G01N33/15
Inventor 赵志全
Owner LUNAN HOPE PHARM CO LTD
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