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A method of improving nutrient utilisation by a mammal and a composition for use therein

A nutritional composition, mammalian technology, applied in the field of oral administration of nutritional composition

Inactive Publication Date: 2007-06-20
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, however, even these liquid formulations do not provide adequate relief to the many patients who barely consume sufficient amounts of these products to meet their nutritional needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The effect of lactoferrin on gastric emptying and nutrient intake in mammals was studied in vivo using a model in which reduced nutrient intake was induced.

[0061] 24 male Wistar rats weighing 300-350 g were selected for this study and randomly divided into 4 groups with 6 rats in each group. Two groups of rats received continuous infusion of TNF-α (100 μg / kg body weight / day) for 3 days, while the remaining two groups served as control groups. Such treatments are known to generally result in substantially lower feed intake.

[0062] From the day before starting TNF infusion until the end of the experiment (4 days in total), each group of rats received the following:

[0063] Group A: Control group receiving feed

[0064] Group B: TNF group receiving feed

[0065]Group C: Control group receiving feed, fortified with an equal daily amount of 50 mg lactoferrin (lactoferrin replaces an equal amount of protein)

[0066] Group D: TNF group receiving feed, boosted with a...

Embodiment 2

[0070] In vivo studies of the effect of LF on Effects on gastric emptying and nutrient intake in patients.

[0071] Gastric motility, the frequency of gastric contractions, is measured using skin electrodes (electrogastrograph, EGG). use[ 13 C] Caprylic acid breath test, in which a nutritional bolus containing labeled caprylic acid is added to measure gastric emptying. Caprylic acid oxidizes immediately after passing through the stomach and appears in the patient's breath 13 CO 2 . Ingestion marked bolus and emergence 13 CO 2 The time elapsed between indicates how fast the stomach is emptying.

[0072] Gastric emptying was followed by using gamma camera technology. The patient takes a 150ml nutritional bolus supplemented with a solid marker, eg, 20MBq technetium-99m labeled stannous colloid. The amount of solid marker detected by the camera indicates the rate of gastric emptying. Nutrient utilization was measured using a patient-filled questionnaire after the bolus w...

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Abstract

The present invention relates to a method of stimulating nutrient utilisation, especially through improved gastric emptying, comprising oral administration of a nutritional composition. More particularly, the invention is concerned with a method of improving nutrient utilisation by a mammal comprising orally administering a lactoferrin containing nutritional composition to the mammal in an amount effective to reduce the residence time of nutrients in the stomach of the mammal, said composition exhibiting a weight ratio of lactoferrin to beta-lactoglobulin that exceeds 1:15. Another aspect of the invention relates to a pourable nutritional composition suitable for use the aforementioned method, said composition having a caloric content of at lest 1.0 kcal / ml, a viscosity of 100 mPa.s or less at 21 DEG C and comprising: 50-79.6 wt% water; at least 0.4 wt% lactoferrin; 1-30 wt% proteinaceous matter other than lactoferrin; 0.1-20 wt% lipids; and 10-30 wt% carbohydrates; wherein the combination of these components constitutes at least 80 wt% of the composition and wherein the proteinaceous matter, lipids and / or cabohydrates together constitute at least 20 wt% of the composition.

Description

technical field [0001] The present invention relates to a method of stimulating nutrient utilization, particularly by enhanced gastric emptying, comprising oral administration of a nutritional composition. Another aspect of the invention relates to nutritional compositions suitable for use in such methods. Background technique [0002] Nutrient utilization by mammals is influenced by factors such as the mammal's ability to digest food and absorb the nutrients released by the digestive process. Additionally, the ability of mammals to consume adequate amounts of food also determines nutrient utilization. The ability to consume adequate food can be negatively affected by a number of conditions, such as nausea, vomiting and gastrointestinal dysmotility. [0003] Patients who are hospitalized, especially those undergoing chemotherapy or radiation, those with gastrointestinal disorders, and those who have undergone surgery, often suffer from conditions such as nausea and vomitin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/305A61K38/40A23L1/30A23L1/29A61P1/00A23L33/00
CPCA23V2002/00A23L1/3051A23L1/3008A23L1/296A61K38/40A23L1/3056A23L33/12A23L33/175A23L33/19A23L33/40A61P1/00A61P3/02A23V2250/54248A23V2250/0612A23V2250/1882
Inventor 劳拉·姆拉贝贝琳达·波特阿佩尔-范特兰德
Owner NV NUTRICIA
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