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Compound preparation for enhancing memory

A technology for enhancing memory and compound preparations, which can be applied to medical preparations containing active ingredients, pharmaceutical formulations, medical raw materials derived from Ginkgo biloba, etc., and can solve the problems of permanent damage and elevation of central nervous cells.

Inactive Publication Date: 2012-04-04
ANHUI HUIKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the brain is stimulated by these single-targeted products, the level of oxidative stress (OS) in the brain will often increase, which may cause permanent damage to the central nervous cells.

Method used

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  • Compound preparation for enhancing memory
  • Compound preparation for enhancing memory

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Embodiment one sample formula

[0113] This embodiment provides samples 1-6 for comparative tests, wherein sample 1 includes all the necessary active ingredients screened out, sample 2 does not include the active ingredient for controlling oxidative stress, i.e. adjuvant, and sample 3 is Including various ingredients of monarch and minister adjuvant drugs, but the compound preparation containing the least active ingredients obtained through optimization, sample 4 does not include the active ingredient for enhancing the oxygen supply of the central nervous system of the brain, that is, the main minister drug part, sample 5 does not Including the primary drug, Sample 6 is only an adjuvant that is an active ingredient for controlling oxidative stress.

[0114] The active ingredients and contents involved in the samples are shown in Table 1:

[0115] Units not indicated in Table 1 are milligrams

[0116] Table I

[0117]

[0118] L-tryptophan

Embodiment 2

[0119] Embodiment two efficacy application test

[0120] Comparison of Oxidative Stress States in the Brain

[0121] Animal experiments were carried out with the sample composition of Example 1 to test the effect of these samples on oxidative stress. Animals Six-month-old WISTAR male mice were used. Test rats were housed in a standard animal testing environment, with water and food readily available, on a 12-hour day / night cycle. They were divided into seven groups with 10 rats in each group. The first group is the blank group, which is fed with saline; the test mice in the other groups are fed with the preparations of samples 1-6. The feeding amount was compared with 5-hydroxytryptophan or acetyl-L-carnitine in the sample formulation (1.5 mg / kg body weight). Eight hours later, the test mice and the control group were all killed by head and neck dislocation under ether anesthesia. The prefrontal cortex and hippocampus in the rat brain were picked under ice-cold conditions...

Embodiment 3

[0134] Effects on learning ability and memory (normal state of health, and abnormal state of brain cognitive deficits)

[0135] A: Object Recognition Test in Normal Health

[0136] The test used 10-week-old C57BL / 6J male mice, and the test mice were randomly divided into eight groups, ten in each group. The first group is a blank group, fed with saline; the second group is a positive control group, intraperitoneally injected Rolipram (Rolipram, 10% DMSO solution, 0.1mg / kg body weight); all the other groups of test mice are fed with sample 1-6 preparations . The feeding amount was compared with 5-hydroxytryptophan or acetyl-L-carnitine in the sample formulation (1.5 mg / kg body weight). 60 minutes before the test if fed or 20 minutes before the test if injected.

[0137] All test rats were put into the test environment for at least one hour before the test to familiarize themselves with the environment. At this time, there were two small external objects in the test environme...

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Abstract

The present invention discloses small molecular compound Western medicine developing method, and the method is verified with one compound preparation for enhancing memory. The compound preparation for enhancing memory contains medicine for stimulating memory related function, matrix and course of brain, medicine for increasing the oxygen and nutrient supply, and medicine for maintaining normal oxidation stress level of brain. The compound preparation may be orally taken to enhance memory, prevent the ascent of oxidation stress level in central nervous system, enhance learning capacity, treat cognitive disorder disease, and prevent and treat Alzheimer disease.

Description

Technical field [0001] The invention belongs to the technical field of development of new drug varieties, and in particular relates to a development method of a brand-new small molecular compound western medicine and a compound preparation for enhancing memory. Background of the invention [0002] With the development of science and the advancement of technology, human beings have gradually deepened their knowledge and understanding of nature and themselves, and all kinds of knowledge have grown explosively. People need to master more and more knowledge and skills. It is increasingly important to develop products that effectively enhance human memory. [0003] The development of a new class of new small molecule drugs (New Chemical Entity) includes many aspects of work. The development direction of a single small molecule compound is generally a single targeted product. The development work first needs to find a new biological treatment target (Target), and then use the obt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K38/06A61K36/16A61K33/04A61K33/30A61K33/00A61K31/7076A61K31/6615A61K31/4375A61K31/4184A61K31/405A61K31/435A61K31/198A61K31/352A61K31/385A61K31/205A61K31/047A61K31/4415A61K31/51A61K31/525A61K31/355A61K31/375A61K31/01A61P25/00A61P25/28
CPCA61K31/519A61K31/198A61K31/205A61K31/405A61K31/4188A61K31/221A61K31/352A61K31/385A61K31/375A61K45/06A61K31/525A61K31/202A61K31/355A61K31/7076A61K31/455A61K31/4415A61K33/04A61K31/51A61K38/063A61K31/7048A61K33/30A61K36/16A61K31/685A61P25/00A61P25/28A61K2300/00
Inventor 叶红平孙萌朱作霖
Owner ANHUI HUIKE PHARMA
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