Support with crosslinked marine collagen for tissue engineering and manufacture of biomaterials

a technology of crosslinked marine collagen and biomaterials, which is applied in general culture methods, epidermal cells/skin cells, skeletal/connective tissue cells, etc., can solve the problems of not providing collagen supports which satisfactorily comply with all research results
US20050208478A1Inactive Publication Date: 2005-09-22COLETICA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
COLETICA
Publication Date
2005-09-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising at least one porous collagen layer covered on at least one side with a collagen membrane component selected from the group consisting of a collagen membrane prepared by compression of a collagen sponge at a pressure of at least about 50 bar and of a collagen membrane comprising a collagen film prepared by drying a collagen gel separately from the porous collagen layer, thereby providing a reliable method for finding new potentially active substances.
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Description

[0001] This application is a Divisional and Continuation in Part of U.S. patent application Ser. No. 09 / 616,282 filed on Jul. 14, 2002, and of U.S. patent application Ser. No. 09 / 616,526 filed on Jul. 14, 2002.

[0002] The invention relates to a support with collagen base for tissue engineering and manufacture of biomaterials and to different methods including a method of in vitro testing of the efficacy of a potentially active substance using such a support.DISCUSSION OF THE PRIOR ART

[0003] For many years collagen has proved to be an irreplaceable substrate for the production of artificial tissues containing living cells.

[0004] The biomaterials obtained are increasingly used in the field of pharmaceutics and they appear to have a very promising future for the preparation of injured connective tissues or for gene therapy by allowing the introduction and survival of modified cells in a living organism.

[0005] Furthermore, for “in vitro” tests, the cosmetic and dermopharmaceutical in...

Claims

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