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Processs for production and purification of fermentation derived organic acids

a technology of organic acids and purification processes, applied in the field of process for the production and purification of fermentation derived organic acids, can solve the problems of prohibitively expensive process for lower value acids, few separation processes have succeeded technically

Inactive Publication Date: 2005-12-08
UCHICAGO ARGONNE LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005] It is an object of the present invention to provide an improved process for the production and purification of fermentation or bioconversion derived organic acids.

Problems solved by technology

So far, few separation processes have succeeded technically.
However, the capital and operating cost and the stringently low divalent ion requirement of the bipolar membranes for WSED step make this process prohibitively expensive for lower value acids.

Method used

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  • Processs for production and purification of fermentation derived organic acids
  • Processs for production and purification of fermentation derived organic acids

Examples

Experimental program
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Effect test

example 1

[0015] A simple apparatus was set up to sublimate ammonium acetate solutions at controlled temperatures between 100° C. and 120° C. An HPLC based method was also developed to quantify acetic acid and acetamide concentrations.

[0016] Preliminary results from the initial experiments showed: [0017] 1a. The rate of sublimation increases with temperature and very good rates can be attained at a temperature of 120° C. [0018] 1b. Under these conditions of free sublimation of ammonium acetate solution, the rate of the byproduct acetamide formation is significantly lower than the rate of volatilization. In these experiments the ratio of rates were about 1:50 to 1:100. This means the kinetics are favorable for acetic acid formation and there is not a fundamental kinetic barrier to the development of a high yield separations process.

[0019] Further tests conducted at even higher temperatures of 125° C. and 140° C. in aclosed reactor showed that the rate of acetamide formation from an 80% w / w s...

example 2

[0022] The Sulzer membranes identified above were tested with liquid phase feed of ammonia, water and ethanol and found that one of the membrane types, Sulzer # 2211, had good water flux, and moderate ammonia flux and the ammonia fluxes increased considerably (˜2.5 fold) with temperature increase from 100° C. to 120° (Table 3).

TABLE 3Acid-Tolerant Membrane Flux ComparisonAll tests conducted with Sulzer Circular, Flat-SheetPervaporation Module in Liquid-Phase ModeReactorWaterConc.WaterRunSulzerAvg. ReactorReactor NH3NH3range,Flux,No.MembraneTemp., ° C.Conc. range, wt %Flux, kg / m2-hrwt %kg / m2-hr421201-D972.6-2.4%˜0.058.1-5.5%˜0.5431201-D1172.6-2.1%˜0.157.4-2.3%˜1.3501211-NV982.6-2.4%˜0.068.5-6.3%˜0.5511211-NV1202.6-2.1%˜0.207.0-2.6%˜1.25222111002.6-2.3%˜0.117.2-4.2%˜0.85322111202.5-1.8%˜0.287.0-1.8%˜1.4

[0023] A vapor permeation module was designed and assembled with #2211 membrane (0.022 m2 membrane area) and tested its performance with water, ethanol and ammonia vapor feed and esta...

example 3

[0024] For this experiment an 80% (w / w) ammonium acetate solution in water was prepared and heated in a closed reactor to 135° C. and allowed the pressure to build. At the same time the vapor permeation module with the #2211 membrane (0.022 m2) was preheated to ˜120° C. This was necessary to insure that no liquid acetic acid or water would condense on the membrane surface during the test run.

[0025] At the beginning of the run the vapor release valve at the top of the reactor was opened and after the vapor passed over the module it was condensed and collected in an enclosed condenser. The permeate from the module was condensed in a cold (0° C.) condenser and any uncondensed permeate vapors were collected in an acid trap (containing ˜25% sulfuric acid) and a cold trap (−50 C). The test run lasted for ˜15 minutes after which no more vapor was being produced by the reactor. Samples from the reactor, condensate, permeate, traps and the vapor were taken and carefully analyzed for free am...

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Abstract

A method of producing and purifying an organic acid by producing an aqueous solution of the ammonium salt of the organic acid through fermentation and / or bioconversion and neutralization. The solution is heated to thermally crack the ammonium salt of the organic acid producing a vapor phase of ammonia and water and organic acid which is thereafter passed in contact with a membrane permeable to water and ammonia and substantially impermeable to the organic acid vapor to concentrate the aqueous solution of organic acid, and remove the ammonia and excess water.

Description

CONTRACTUAL ORIGIN OF THE INVENTION [0001] The United States Government has rights in this invention pursuant to Contract No. W-31-109-ENG-38 between the U.S. Department of Energy (DOE) and The University of Chicago representing Argonne National Laboratory.FIELD OF THE INVENTION [0002] This invention related to an improved process for the production and purification of fermentation derived organic acids. More specifically this invention relates to an improved method for the recovery and purification of fermentation derived organic acids from their ammonium salts. BACKGROUND OF THE INVENTION [0003] Fermentation or bioconversion of many inexpensive and widely available feedstocks to organic acids is well known. These fermentations or bioconversions to produce organic acids operate best at near neutral pH. As the pH drops during fermentation, the metabolism of the organisms and functionality of the key enzymes decreases sharply. This sensitivity to low pH is presently overcome by neutr...

Claims

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Application Information

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IPC IPC(8): C07C51/02C07C51/42C12P7/40C12P7/42C12P7/52C12P7/54
CPCC07C51/02C07C51/42C12P7/40C12P7/42C12P7/52C12P7/54C07C53/122C07C53/08
Inventor DATTA, RATHINHENRY, MICHAELMARTIN, EDWARD J. ST.
Owner UCHICAGO ARGONNE LLC
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