Nucleic acid and amino acid sequences relating to Enterococcus faecalis for diagnostics and therapeutics

a technology of enterococcus faecalis and nucleic acids, applied in the field of enteroco-derived isolating nucleic acids and polypeptides, can solve the problem of limited treatment options for physicians

Inactive Publication Date: 2007-01-25
OSCIENT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Benefits of technology

[0015] A variety of data storage structures are available to a person skilled in the art for creating a computer readable media having recorded thereon a nucleotide sequence of the present invention. The choice of the data storage structure will generally be based on the means chosen to access the stored information. In addition, a variety of data processor programs and formats can be used to store the nucleotide sequence information of the present invention on computer readable media. The sequence informat

Problems solved by technology

Treatment options for physicians are limited, with the latest strategy being combi

Method used

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specific example

Determination of Enterococcus Protein Antigens for Antibody and Vaccine Development

[0160] The selection of Enterococcus protein antigens for vaccine development can be derived from the nucleic acids encoding E. faecalis polypeptides. First, the ORF's can be analyzed for homology to other known exported or membrane proteins and analyzed using the discriminant analysis described by Klein, et al. (Klein, P., Kanehsia, M., and DeLisi, C. (1985) Biochimica et Biophysica Acta 815, 468-476) for predicting exported and membrane proteins.

[0161] Homology searches can be performed using the BLAST algorithm contained in the Wisconsin Sequence Analysis Package (Genetics Computer Group, University Research Park, 575 Science Drive, Madison, Wis. 53711) to compare each predicted ORF amino acid sequence with all sequences found in the current GenBank, SWISS-PROT and PIR databases. BLAST searches for local alignments between the ORF and the databank sequences and reports a probability score which i...

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Abstract

The invention provides isolated polypeptide and nucleic acid sequences derived from Enterococcus faecalis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

Description

[0001] This application claims priority of U.S. Provisional application 60 / 055,778, filed Aug. 15, 1997, all of which is hereby incorporated herein by reference in its entirety.FIELD OF THE INVENTION [0002] The invention relates to isolated nucleic acids and polypeptides derived from Enterococcus faecalis that are useful as molecular targets for diagnosis, prophylaxis and treatment of pathological conditions, as well as materials and methods for the diagnosis, prevention, and amelioration of pathological conditions resulting from bacterial infection. BACKGROUND OF THE INVENTION [0003]Enterococcus faecalis (E. faecalis) is a gram-positive, facultative, anaerobic cocci, that is widely distributed in nature, animals, and humans. Enterococci are part of the normal gastrointestinal and genital tract flora, and among the 17 known species, E. faecalis is dominant in humans, accounting for 80-90% of clinically isolated specimens, and it exhibits increasing levels of multidrug resistance (Ka...

Claims

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Application Information

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IPC IPC(8): C07H21/04C12P21/02C12N1/21C07K14/24C07K14/315C12N1/13C12N15/31C12Q1/68
CPCC12Q1/689C07K14/315
Inventor DOUCETTE-STAMM, LYNNBUSH, DAVID
Owner OSCIENT PHARMA
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