Polynucleotide Fragments of an Infectious Human Endogenous Retrovirus

a technology polynucleotide fragment, which is applied in the field can solve the problems that the infection of human endogenous retrovirus cannot be isolated or detected so far, and achieve the effect of improving antisense agent and greater resistance to enzymatic degradation
US20080008717A1Inactive Publication Date: 2008-01-10BAXTER HEALTHCARE SA
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
BAXTER HEALTHCARE SA
Publication Date
2008-01-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

Nucleotide sequences and fragments which code for a human endogenous retrovirus which is infectious. "Fragments" according to the present invention relate also to specific fragments of the sequences inserted into the vector pCR4-Topo and deposited as MERV-env, MERV-gag, MERV-prt and MERV-pol as mentioned above. Additionally, methods of using such sequences, polypeptides encoded by such sequences, antibodies directs against such sequences, and methods and compositions relating to the same are all contemplated.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional of co-pending U.S. application Ser. No. 10 / 490,920 filed 26 Mar. 2004, which is a national phase application under 35 U.S.C. § 371 of International Application No. PCT / EP02 / 10899 filed 27 Sep. 2002, which claims priority to Austrian Application No. A 1539 / 2001 filed 27 Sep. 2001, the contents of which are incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] The present invention relates to human endogenous retroviruses, fragments thereof, a biologically functional vector comprising sequences of said retrovirus.

[0004] 2. Description of Related Art

[0005] Endogenous retroviruses (ERVs) are integral parts in the genomes of many, if not of all, species. ERVs most probably resulted from infection of germ line cells with exogenous retroviruses and subsequent fixation of their genetic information in the host genome.

[0006] Many types of human en...

Claims

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