Glycoprotein VI fusion proteins

a technology of glycoprotein and fusion protein, which is applied in the field of glycoprotein vi (gpvi) fusion protein, can solve the problems of high cost of therapy and difficulty in purification, and achieve the effects of easy purification, enhanced circulating half-life and easy detection
US20080206247A1Inactive Publication Date: 2008-08-28BURGER CHRISTA +2
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
BURGER CHRISTA
Publication Date
2008-08-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to Glycoprotein VI (GPVI) fusion proteins (GPVI-fusion proteins) comprising a tag like myc, GST, HA, FLAG, STREP but preferably a Immunoglobulin molecule (Ig), more preferably a Fc portion of said Ig and a protein or oligopeptide having the biological activity of GPVI (GPVI-like protein) which is binding to collagen and their use in methods and kits for the screening of potential agonists or antagonists for GPVI-collagen and / or platelet-collagen interaction is disclosed.Further, pharmaceutical compositions and therapeutic methods are provided comprising such GPVI-fusion proteins for the treatment of thrombotic and cardiovascular events and disorders related to GPVI-collagen and / or platelet-collagen interactions.
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Description

[0001] This application is a divisional application of U.S. application Ser. No. 10 / 483,810, filed on Jan. 15, 2004, which is the National Stage application under §371 of PCT / EP02 / 07796, filed Jul. 12, 2002.FIELD OF THE INVENTION

[0002] The present invention relates to Glycoprotein VI (GPVI) fusion proteins (GPVI-fusion proteins) comprising a tag like myc, GST, HA, FLAG, STREP but preferably a immunoglobulin molecule (Ig), more preferably a Fc portion of said Ig and a protein or oligopeptide having the biological activity of GPVI (GPVI-like protein) which is binding to collagen.

[0003] Procedures for production and purification of said fusion proteins are disclosed. Methods and kits for the screening of potential agonists or antagonists for GPVI-collagen and / or platelet-collagen interactions are provided.

[0004] The GPVI-fusion proteins are useful for the treatment of thrombotic and cardiovascular events and disorders related to GPVI-collagen and / or platelet-collagen interactions. Furtherm...

Claims

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