Anti-platelet membrane glycoprotein vi monoclonal antibody

US20090041783A1Inactive Publication Date: 2009-02-12MOCHIDA PHARM CO LTD
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
MOCHIDA PHARM CO LTD
Publication Date
2009-02-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof:a) It specifically binds to human platelet membrane glycoprotein VI (GPVI);b) The function to activate a platelet and / or the function to induce a thrombocytopenia in vivo are low; andc) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
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Description

TECHNICAL FIELD

[0001] The present invention relates to an antibody to human platelet membrane glycoprotein VI (hereinafter, sometimes abbreviated as GPVI) and a recognition region of the antibody.BACKGROUND ART

[0002] The platelet plays a very important role in the clot formation and the biophylaxis, and its concerning in various clinical condition is being elucidated from the physiological role. In particular, it is remarkable about the function that the platelet forms a hemostatic plug. For example, when the vascular endothelial cell suffers damage, the collagen that is the major matrix protein of the subcutaneous vascular endothelium is exposed and the platelet adheres thereto. Next, the platelet is activated by the signal from the collagen and when finally, the platelet agglutinates through the fibrinogen. Then, since this fact causes morbidity such as thromboembolic disease depending on the situation, it is remarkable as a target for therapy.

[0003] In the past, for the purpose of t...

Claims

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