Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Automatic Liquid Injection System and Method

a liquid injection system and liquid injection technology, applied in the field of administration, can solve the problems of insufficient breakage or damage of particles, and disturb their distribution,

Inactive Publication Date: 2009-03-19
BRACCO RES USA
View PDF5 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]The embodiments disclosed below in connection with the annexed drawings provides very effective means to keep the syringe content under sufficient agitation to secure injection of a homogeneous therapeutic or diagnostic liquid compositions into a patient.

Problems solved by technology

In the case of particles not sensitive to external fields, mechanical agitation is provided to the extent that it is sufficient to keep the suspension homogeneous but insufficient to break or damage the particles or disturb their distribution.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Automatic Liquid Injection System and Method
  • Automatic Liquid Injection System and Method
  • Automatic Liquid Injection System and Method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0033]A solution of gas filled microbubbles stabilised by a phospholipids interface was prepared according to Example 1 of U.S. Pat. No. 5,445,813. The dry matter concentration was 5 mg / ml in a saline solution (0.9% NaCl). Typically, the bubble size distribution extended from 0.2 to 15 μm. The concentration of bubbles between 2 and 5 μm was 5×107 microbubble / ml.

[0034]The solution was transferred in a 50 ml plastic syringe and samples were taken in time intervals for analysis. This represent the starting 100% of the bubble concentration. The syringe was mounted in the infusion unit and the elution started. The elution flow was fixed at 1.6 ml / min.

[0035]Aliquots of the eluted solution were analysed by Coulter measurement (bubbles distribution; size and concentration) and imaging.

TABLE 1RadiusVa1.00.1311.50.2942.00.5232.50.8173.01.1773.51.6024.02.0924.52.6485.03.2695.53.9556.04.7076.55.5247.06.4077.57.3558.08.3688.59.4469.010.5909.511.80010.013.07510.514.41511.015.82011.517.29112.018.8...

example 2

Preparation of Contrast Agents for Infusion

[0042]To test the efficiency of the present invention (a system of rotary syringe pump), different contrast agents for ultrasound echography were prepared.

[0043]Microbubble Suspensions

[0044]Phospholipid stabilised microbubbles were obtained in the following manner. 500 mg DAPC and 50 mg DPPA (Avanti Polar Lipids, Inc.) were dissolved in hexane / iso-propanol 8 / 2 (v / v) and dried in a round-bottomed flask using a rotary evaporator and, further, in a vacuum dessicator. After addition of water (100 ml), the suspension of lipids was heated at 75° C. for 1 hour under agitation and then extruded through a 0.8 μm polycarbonate filter (Nuclepore®). The resulting suspension and 10 g of poly-ethyleneglycol (Mw4000) were mixed and lyophilised. 2 g of the lyophilisate was introduced into a glass vial and sealed under SF6 or an air / C4F10 mixture. After reconstitution with 25 ml NaCl 0.9%, the resulting suspensions contained about 6×108 (SF6) or 1×109 (C4F1...

example 3

Determination of the Limit of Rotation Rate for the Syringe Used for Infusion

[0047]The effect of syringe rotation on stability of gas microbubble suspensions in the syringe used for infusion has been tested using a 50 ml syringe which was mounted on a rotation system which allows very low rotation speeds (about 1 rpm). Prior to its mounting the syringe was filled with 30 ml of phospholipid stabilised microbubble suspension. The mounted syringe was then rotated at different speeds: 0 (no rotation) 1.3, 2 and 60 rpm (1 Hz) and the suspension monitored taking one sample every 5 minutes. The samples were then analysed using Coulter counter. Table 3A shows the results obtained with a suspension of 3.1×108 microbubbles / ml having a mean diameter of 2.1 μm.

TABLE 3AHomogeneity of microbubble suspensions in the syringeas a function of the rotation rate and time (microbubbleconcentration 3.1 × 108 bubbles / ml)Syringe rotation ratesrpm01.326001.326001.3260Vrt011417652780114176527801142765278(min...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
angleaaaaaaaaaa
angleaaaaaaaaaa
angleaaaaaaaaaa
Login to View More

Abstract

A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.

Description

FIELD OF THE INVENTION[0001]The present invention concerns the administration by injection to patients of liquid compositions for therapeutic or diagnostic purposes. It more particularly concerns a power assisted method and device for controllably dispensing a liquid medicament or diagnostically active contrast agent, the homogeneity of which is preserved throughout delivery. Typically, the contrast agent is an aqueous suspension of gas filled microvesicles, namely microbubbles bounded by a surfactant stabilized gas / liquid interface, or microballoons bounded by a tangible material envelope.BACKGROUND ART[0002]Power injectors and mechanically assisted infusion systems for controllably dispensing therapeutically active medications are well known in the art. Typically, such devices include an automatic injector for syringes containing an injectable liquid and a plunger or piston movable within the barrel of the syringe to expel said liquid through a tip thereof and injecting into a pat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61M5/00A61B6/00A61B17/22A61B19/00A61K9/22A61M5/145B01F9/00B01F11/00
CPCA61B2017/22008A61B2019/5425A61B2019/5433A61M5/007B01F2003/0035A61M2205/6072B01F9/0016B01F11/0002A61M5/1456A61B2090/3925A61B2090/3933B01F23/024B01F29/31B01F31/10B01F35/332
Inventor SCHNEIDER, MICHELGOLAY, CHRISTOPHEJAKOB, LAURENTBROCHOT, JEANYAN, FENGMATHIEU, CHRISTIAN
Owner BRACCO RES USA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com