Hydroswellable, Segmented, Aliphatic Polyurethanes and Polyurethane Ureas
a polyurethane urea and water-welling technology, applied in the direction of impression caps, prostheses, drug compositions, etc., can solve the problems of chemical degradation, prior art is virtually silent on self-standing peu and peu liquid solventless compositions, etc., and achieve the effect of restoring the function of diseased or defective articulating joints and increasing volum
Examples
example 1
Synthesis and Characterization of a Typical Polyether-carbonate-urethane, P-1
[0023]For an initial charge, poly(ethylene glycol) (Mn=400 Da) (0.15 moles) and tin(II) 2-ethyl hexanoate (3.53×10−4 moles) were added to a 500 mL, 3-neck, round-bottom flask equipped with a PTFE coated magnetic stir bar. The contents were heated to 70° C. and allowed to stir for 10 minutes. For a second charge, trimethylene carbonate (0.882 moles) was added and the contents were heated to 135° C. Conditions were maintained until practically complete monomer conversion was achieved. The magnetic stir bar was removed and replaced by a stainless steel mechanical stirrer. The polymer was cooled to room temperature. For a third charge, 1,6-diisocyanatohexane (0.12 moles) was added and the contents were stirred until complete mixing was achieved. The contents were stirred and heated to 100° C. Conditions were maintained for 1.25 hours. The polymer was allowed to cool to room temperature and then dissolved in an ...
example 2
Synthesis and Characterization of Liquid Polyether-ester-urethane: General Method
[0024]For an initial charge, poly(ethylene glycol) (Mn=400 Da) and tin(II) 2-ethyl hexanoate were added to a 500 mL, 3-neck, round-bottom flask equipped with a PTFE coated magnetic stir bar. The contents were heated to 70° C. and allowed to stir for 10 minutes. For a second charge, dl-lactide and glycolide were added and the contents were heated to 135° C. Conditions were maintained until practically complete monomer conversion was achieved. The magnetic stir bar was removed and replaced with a stainless steel mechanical stirrer. The polymer was cooled to room temperature. For a third charge, 1,6-diisocyanatohexane was added and the contents were stirred until complete mixing was achieved. The contents were stirred and heated to 100° C. Conditions were maintained for 1.25 hours. The polymer was allowed to cool to room temperature and then dissolved in an equal part of tetrahydrofuran. The polymer soluti...
example 3
Synthesis and Characterization of Typical Polyether-ester-urethanes Using the General Method of Example 2, P-2, P-3, and P-4
[0025]Polyether-ester-urethanes P-2, P-3, and P-4 were prepared using the method of Example 2 with 0.15, 2.225, 0.15 moles of polyethylene glycol (M, =400 Da), 2.60×10−4, 3.18×10−4, 2.60×10−4 moles of tin(II) 2-ethyl hexanoate, 0.52, 0.64, 0.52 moles of dl-lactide, 0.13, 0.16, 0.13 moles of glycolide, and 0.18, 0.18, 0.12 moles of 1,6-diisocyanatohexane, respectively. Polymers P-2, P-3, and P-4 were characterized for molecular weight by GPC using tetrahydrofuran as the mobile phase which resulted in Mn of 11, 9, and 9 kDa, Mw of 20, 14, and 15 kDa, Mp of 20, 12, 14, kDa, and PDI of 1.9, 1.6, and 1.6, respectively. Identity and composition were confirmed by FT-IR and NMR, respectively.
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Abstract
Description
Claims
Application Information
- IPC
- A61K31/65; C08G18/00; A61K47/34; A61L24/04; C08G77/04
- CPC
- A61L24/0021; C08G64/0241; A61L27/52; A61L2430/06; C08G18/12; C08G18/4244; C08G18/428; C08G18/4283
- Inventors
- SHALABY, SHALABY W.; CORBETT, JOEL T.