Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Valve

a valve and esophageal technology, applied in the field of esophageal stents, can solve the problems of significant discomfort of patients, in-stent reflux technology, and reduce the quality of life of already sick patients, and achieve the effect of reducing the diameter of at least a portion of the valve support structur

Inactive Publication Date: 2010-05-13
VYSERA BIOMEDICAL
View PDF72 Cites 104 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0002]An esophageal stent is often placed across the lower esophageal sphincter (LES) to treat benign strictures or malignant obstructions. However, the consequent loss of a reflux barrier often results in significant amounts of acid reflux, which can reduce the quality of life of an already sick patient.

Problems solved by technology

However, the consequent loss of a reflux barrier often results in significant amounts of acid reflux, which can reduce the quality of life of an already sick patient.
However, there are a number of problems with existing in-stent reflux technology.
When a patient wishes to belch or vomit many of these devices will seal completely preventing retrograde flow and causing the patient significant discomfort.
In some cases the sleeves can invert to allow retrograde flow but may then remain inverted and may cause blockage of the esophagus.
In addition, because such sleeves are generally at the distal end of the stent where peristalsis is not effective, there is a risk of food becoming stuck in this portion of the device.
Another problem is that the materials that these valves are made from often degrade in the gastric environment thus reducing the efficacy of the devices over time.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Valve
  • Valve
  • Valve

Examples

Experimental program
Comparison scheme
Effect test

example 1

Synthesis of Aliphatic Linked Fluorosiloxane Based Triblock Copolymer Pre-Soft-Segment

[0309]This is a 2 step process. In the first step silanol terminated poly(trifluoropropyl methyl siloxane) is converted into its dihydride derivative. In the next step, this dihydride derivative is reacted with the allyl terminated poly(propylene glycol).

[0310]The synthetic procedure is as follows:

[0311]Step 1:

[0312]To a 4 neck separable flask fitted with mechanical stirrer, was added 40 g of Silanol terminated poly(trifluoropropyl methylsiloxane) (FMS-9922 from Gelest Inc.) and this was mixed with 50 ml of toluene and fitted with a continuous flush of Nitrogen. To the reaction mixture 7.57 g of dimethyl chlorosilane (DMCS, from Sigma Aldrich) was added slowly over about 20 minutes keeping the temperature of the mixture constant at 30° C. With each addition of dimethyl chlorosilane, the mixture became hazy but cleared in a short period of time. Once the addition of dimethyl chlorosilane was complet...

example 2

Synthesis of Aliphatic Linked Dimethylsiloxane Based Triblock Copolymer Pre-Soft-Segment

[0315]To 130 ml of reagent grade toluene in a separable flask fitted with a mechanical stirrer, was added 64 g of allyl terminated poly(propylene glycol) (MW=700 g / mol, Jiangsu GPRO Co.) and both were mixed and heated to reflux. Then 40 g of hydride terminated poly(dimethyl siloxane) (Silmer H Di 10 by Siltech Corp.) was dissolved in 50 ml reagent grade toluene and the temperature raised to around 90° C. To this reaction mixture 2 drops of hexachloroplatinic(IV) acid (0.01M H2PtCl6 from Sigma) solution in isopropanol was added. After this catalyst solution was added, the mixture was refluxed for 1 hour and then the solvent was distilled off in order to get the final product. The reaction was followed with H-NMR and gel permeation chromatography (GPC) confirmed the final molecular weight of the product to be 2300 g / mol.

TABLE 2Polymer block ratiosStoiciometric ratios for reaction product:Polymer bl...

example 3

Synthesis of Aromatic Linked Siloxane Based Triblock Copolymer Pre-Soft-Segment

[0316]

[0317]To a 100 ml separable flask fitted with a mechanical stirrer, 15 g of hydroxy terminated polydimethyl siloxane (DMS-S14 from Gelest Inc.) was added along with 5.36 g of di-chloro p-xylene (from Sigma) and 0.0089 g of Copper(II) acetylacetonate (Cu(Acac)2 from Sigma). The reaction mixture was refluxed at 110° C. for 5 hrs. At this point, 19.77 g of hydroxy terminated poly(propylene glycol) (from Sigma) was added dropwise and the reaction mixture was then refluxed for another 15 hr. The progress of reaction was followed by 1H-NMR and the final molecular weight, determined by gel permeation chromatography (GPC), was 3000 g / mol.

[0318]H-NMR analysis: Solvent used for 1H-NMR analysis is CDCl3.

[0319]Aromatic H=7.25-7.45 ppm, —CH2=4.5-4.6 ppm, —CH3 (of PPO)=1-1.4 ppm, —CH2 (of PPO)=3.2-3.8 ppm, —OH (of PPO)=3.8-4 ppm, —CH3(silanol)=0.5-0.8 ppm.

TABLE 3Resulting polymer block ratiosStoiciometric ratios ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Login to View More

Abstract

A valve such as an esophageal valve has a normally closed configuration in which the valve is closed and an open configuration in which the valve is opened for flow through the valve. A support for the valve is adapted for mounting to a pre-deployed luminal prosthesis intermediate a proximal end and a distal end of the predeployed luminal prosthesis.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application claims the benefit of U.S. Provisional Patent Application Nos. 61 / 074,393 filed Jun. 20, 2008; 61 / 074,400 filed Jun. 20, 2008; 61 / 145,337 filed Jan. 16, 2009; 61 / 145,332 filed Jan. 16, 2009; 61 / 151,968 filed Feb. 12, 2009; 61 / 151,973 filed Feb. 12, 2009; 61 / 174,536 filed May 1, 2009; and 61 / 181,043 filed May 26, 2009, the entire contents of all of which are incorporated herein by reference.INTRODUCTION[0002]An esophageal stent is often placed across the lower esophageal sphincter (LES) to treat benign strictures or malignant obstructions. However, the consequent loss of a reflux barrier often results in significant amounts of acid reflux, which can reduce the quality of life of an already sick patient.[0003]Such esophageal stents that are placed across the gastric cardia are sometimes equipped with a flexible sleeve that hangs below the stent into the stomach. These so called ‘windsock’ devices rely on the slightly...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61F2/04
CPCA61F2/04A61F2002/044A61F2/2418A61F2/2412A61F2/90A61F2002/045C08L83/10
Inventor SOBRINO-SERRANO, GABRIELBEHAN, NIALLO'HALLORAN, ANTHONY
Owner VYSERA BIOMEDICAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com