Agent having neurotrophic factor-like activity

a neurotrophic factor and agent technology, applied in the field of agents having neurotrophic factorlike activity, can solve the problems of having difficulty in reaching the brain, affecting the ability of neurons to regenerate, and affecting the ability of neurons to be activated, so as to achieve preventive and improve, high safety, and preventive
US20100204498A1Inactive Publication Date: 2010-08-12NAGOYA INDUSTRIAL SCIENCE RESEARCH INST
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
NAGOYA INDUSTRIAL SCIENCE RESEARCH INST
Publication Date
2010-08-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a pharmaceutical agent having high safety and a neurotrophic factor-like activity, which contains, as an active ingredient, any one compound included in fatty acids each having 8 carbon atoms (C8) or having 10 carbon atoms (C10) to 12 carbon atoms (C12) or fatty acid esters thereof, such as 3,7-dimethyloctanoic acid ethyl ester, geranic acid ethyl ester, and the like, each of which has 8 carbon atoms (C8), decanoic acid methyl ester, trans-2-decenoic acid, trans-2-decenoic acid methyl ester, trans-2-decenoic acid ethyl ester, trans-2-decenoic acid-2-decenyl ester, trans-2-decenoic acid cyclohexyl ester, trans-2-decenoic acid isopropyl ester, trans-3-decenoic acid methyl ester, trans-9-decenoic acid methyl ester, and the like, each of which has 10 carbon atoms (C10), trans-10-undecenoic acid methyl ester, trans-10-undecenoic acid ethyl ester, and the like, each of which has 11 carbon atoms (C11), and dodecanoic acid, and the like, each of which has 12 carbon atoms (C12), or salts thereof or prodrugs thereof.
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Description

TECHNICAL FIELD

[0001] The present invention relates to an agent having a neurotrophic factor-like activity, which is useful for nervous disorders such as neurodegenerative diseases and depression due to promotion of activation of nerve cells, by activating signal transmission with a neurotrophic factor-like activity of a nervous growth factor (NGF), a brain-derived neurotrophic factor (BDNF), and the like.BACKGROUND ART

[0002] A nerve cell is a cell having an information transmission function, and its damage emerges as serious loss of a cranial nerve function. Regeneration of an axon can hardly be expected in central nerves of a brain and spinal cord, and thus, when nerve cells have damage or degeneration, activation of the nerve cells is required. A neurotrophic factor is indispensable for activation of nerve cells of central nerves and peripheral nerves such as differentiation of nerve cells, survival sustention, promotion of synapse functions, regeneration and restoration in damage ...

Claims

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