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Low heat capacity composite for thermal cycler

a composite and thermal cycler technology, applied in biochemical apparatus and processes, specific use of bioreactors/fermenters, biomass after-treatment, etc., can solve the problems of low heat capacity of heat block, difficult use of aluminum in high-speed pcr, and high heat conductivity of heat block. , to achieve the effect of low heat capacity, excellent heat property and reduced raw material cos

Inactive Publication Date: 2013-08-15
BIONEER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a low heat capacity composite for a thermal cycler that can be used to improve the manufacturing process and reproducibility of existing PCR thermal cyclers. The composite has low heat capacity, improved physical and mechanical properties, and reduced raw material costs. Additionally, it can shorten the PCR reaction time and save energy when used as a thermal block for a thermal cycler.

Problems solved by technology

Due to the nature of the PCR, temperature rise and fall are repeated, and thus, a heat block having high heat conductivity and low heat capacity is required.
However, heat capacity performance of aluminum used in this PCR thermal cycler is lowered, and thus, aluminum is difficult to use in the high-speed PCR, which is currently the biggest problem.
Also, silver is expensive, and thus, a method for using silver causes economical problems.
Laid-Open Publication No. 2009-0074628 disclose contents with respect to the thermal cycler, but has problems in that heat capacity characteristic is lowered due to use of aluminum, silver, copper, or the like.
5, 542, 60 discloses a method of improving heat transfer by coating aluminum, copper, indium, tin, Pb or the like on a polymer upper plate, dispersing metal particles, but the heat capacity characteristic is limited.
Furthermore, US Patent Laid-Open Publication No. 2008-0003649 discloses use of gallium-indium alloy, but has a problem of high production cost, and US Patent Laid-Open Publication No. 2008-0124722 discloses use of heat pipes in order to reduce the temperature, but has a problem of complicated manufacture.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

examples 7 to 12

Manufacture of Molded product from Tin-Nanodiamond-Silver Composite Powder

[0033]Molding was performed to prepare tin-nanodiamond-silver mixturecompositespecimensbyusingahigh-temperaturepressunder the same conditions as Example 1, except that a mixture of tin, nanodiamond, and silver at aratio of 90:5:5 (Example 7), amixture of tin, nanodiamond, and silver at a ratio of 85:5:10 (Example 8), a mixture of tin, nanodiamond, and silver at a ratio of 75:5:20 (Example 9), a mixture of tin, nanodiamond, and silver at a ratio of 46:5:49 (Example 10), a mixture of tin, nanodiamond, and silver at a ratio of 94:1:5 (Example 11), and a mixture of tin, nanodiamond, and silver at a ratio of 89:1:10 (Example 12) were used. The prepared specimens were subjected to calorimetry under the same condition as Example 1, and the calorimetric results were tabulated in Table 2.

TABLE 2Calorimetric results of tin-nanodiamond-silver mixture compositesHeatHeatvolumetricTinNanodiamondSilverDensityconductivitycapa...

examples 13 and 14

Manufacture of Molded Product from Tin-Copper Composite Powder

[0035]Moldingwasperformedtopreparetin-coppermixturecomposite specimens by using a high-temperature press under the same conditions as Example 1, except that a mixture of tin powder and copper powder at a ratio of 95:5 (Example 13) and a mixture of tin powder and copper powder at a ratio of 90:10 (Example 14) were used.

[0036]The prepared specimens were subjected to calorimetry under the same condition as Example 1, and the calorimetric results were tabulated in Table 3.

TABLE 3Calorimetric results of tin-copper mixture compositesHeatHeatvolumetricTinCopperdensityconductivitycapacityheat capacitySpecimencontentcontent(g / ml)W / (m K)J / (g K)J / (cm3 K)Example 1395% 5%7.17330.1320.2231.600Example 1490%10%7.21823.0660.2151.552Comparative 0%Al 100%2.696179.0000.9142.464example 1

[0037]It can be confirmed from Table 3 that each of the present examples has excellent heat capacity and volumetric heat capacity, as compared with Comparati...

example 15

Manufacture of Molded Product from Tin-Copper-Antimony Composite Powder

[0038]Molding was performed to prepare a tin-copper-antimony mixture composite specimen by using a high-temperature press under the same conditions as Example 1, except that a mixture of tin powder, copper powder, and antimony powder at a ratio of 90:4:6 was used.

[0039]The prepared specimen was subjected to calorimetry under the same condition as Example 1. The results confirmed that that the present example has a heat conductivity of 37.443 W / (m K), heat capacity of 0.238 J / (g K) , and volumetric heat capacity of 1.748 J / (cm3 K) , which were excellent, as compared with Compared example 1 case where the existing aluminum powder was used alone.

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Abstract

Provided is a low heat capacity composite for a thermal cycler . The low heat capacity composite of the present invention is a low heat capacity composite for a thermal cycler capable of overcoming difficulty in manufacture and reproducibility due to uniqueness of the existing PCR thermal cycler only. The low heat capacity composite of the present invention can reduce the cost of raw material and retain excellent heat property due to the improvement in low heat capacity and physical and mechanical properties, thereby remarkably shortening PCR reaction time and saving energy when used as a thermal block for a thermal cycler.

Description

TECHNICAL FIELD[0001]The present invention relates to a low heat capacity composite for a thermal cycler, and more particularly to a low heat capacity composite including tin, and metal except tin, nano-diamond, or a mixture thereof.BACKGROUND ART[0002]Due to the recent development of industry, the number of heat radiating and heating electronic products has increased and techniques for materials having excellent thermoelectric property has been recognized as very important fields. The importance thereof is growing bigger in fields of heat radiating parts of a personal computer, heat radiator of a light emitting diode (LED) , thermal block parts of a thermal cycler. In particular, the thermal cycler is a basic diagonostic equipment necessary for molecular diagonostics, and, as the importance thereof is increasing, heat carrier techniques for high-speed diagonosis are receiving much attention.[0003]A polymerase chain reaction (PCR) thermal cycler is the most important equipment in a ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B01L7/00
CPCB01L7/52B22F2999/00C09K5/14C22C26/00B22F2301/30C22C1/0483C22C13/00C22C1/0416C22C1/0425C22C1/0466C22C13/02B22F2998/10C22C1/1084B22F3/14B22F3/18C22C1/02
Inventor PARK, HAN OHKIM, JAE HA
Owner BIONEER
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