Solid Support for Sample Collection
a solid support and sample technology, applied in the field of biological sample collection, can solve the problems of compromising the identification process, affecting the quality and integrity of analysis, etc., and achieve the effect of not compromising the human identification process and constant colour intensity
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example 1
ing Test
[0111]Aqueous-based solutions were made up of each of the dyes listed in the table below:
NoDye NameDye TypeOther Properties01Alizarin Red SpH dyepH 3.7 (yellow) pH 5.2 (purple), anionicanthraquinone dye02Bromocresol PurplepH dyepH 5.2 (yellow) pH 6.8 (purple),sulfonephthalein indicator03Bromophenol BluepH dyepH 3.0 (yellow) - pH 4.6 (blue),sulfonephthalein indicator04Bromophenol RedpH dyepH 5.2 (orange / yellow) - pH 6.8 (purple)05Bromothymol BluepH dyepH 6.0 (yellow) - pH 7.6 (blue),sulfonephthalein indicator06Bromoxylenol BluepH dyepH 6.0 (yellow) - pH 7.6 (blue),sulfonephthalein indicator07Chlorophenol RedpH dyepH 4.8 (yellow) - pH 6.4 (red),sulfonephthalein indicator08m-Cresol PurplepH dyepH 1.2-2.8 (red - yellow) and pH7.4-9.0 (yellow - purple),09Cresol RedpH dyepH 0.2-1.8 (orange - yellow) and pH7.2-8.8 (yellow -red / purple)10Litmus SolnpH dyeBroad interval pH 4.8 (red) - pH 8.3 (blue),natural dye11Methyl redpH dyepH 4.2 (pink) - pH 6.2 (yellow), monoazodye12Neutral Redbi...
example 2
eparation
[0114]Paper sheets coated with the remaining candidate dyes were generated and subjected to different conditions to assess their stability to; a) ethylene oxide (EtO), b) ultra violet (UV) and c) a combination of elevated temperature and humidity.
[0115]Cellulose-based paper sheets were cut up into 4×6 cm pieces. Aqueous solutions of each dye were prepared as described earlier. Appropriate volumes of the dye solutions were dispensed in petri dishes and the cut papers were placed for a few seconds in the solution using forceps. The dyed papers were subsequently allowed to dry overnight on aluminium foil at ambient temperature. A protective sheet of aluminium foil was place on top to protect the dyed papers from potential contamination, light etc. Names / numbers were added to facilitate identification. After drying, the dyed papers were attached to larger A4 pieces of card producing sample sheets. Multiple sample sheets were generated for each paper type. Controls sheets were a...
example 3
Oxide Treatment
[0116]Chemically coated / impregnated and uncoated papers as obtained in Example 2 were sent to Synergy Health Sterilisation UK Ltd for exposure to EtO. EtO Cycle conditions were based upon those described by Archer et al. (2010 Forensic Sci Intl: Genetics; 4: 239-243) and Shaw et al. (2008 Int J Legal Med; 122: 29-33). The actual EtO cycling conditions used were: Cycle 1, pre-conditioning at 42.0-45.0° C., for 12 h at a relative humidity 64.5-72.8%. EtO sterilisation was carried out at 43.7-46.5° C. for 4 h at 480 mbar. Removal of EtO was achieved by de-gassing at 42.2-46.2° C. for 12 h. Cycle 2; pre-conditioning at 43.6-47.7° C. for 12 h, at a relative humidity of 64.7-72.8%. EtO sterilisation; 44.1-46.7° C. for 4 h at 480 mbar. De-gassing was performed at 43.0-46.2° C. for 12 h. The colour of samples exposed to EtO were compared to the control samples to determine if any colour changes and / or fading had occurred.
[0117]Dye samples that showed little or no colour chang...
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