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Crystal form of pyrroloquinoline quinone sodium salt and preparation method and use thereof

a technology of pyrroloquinoline quinone and crystal form, which is applied in the field of new crystal form can solve the problems of high hygroscopicity and a large extent, affecting the application and storage of pyrroloquinoline quinone sodium salt, etc., and achieves good solid fluidity, high purity, and easy filtering and drying

Active Publication Date: 2019-07-18
ZHEJIANG HISUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent aims to provide new crystal forms of pyrroloquinoline quinone sodium salt with excellent chemical and physical stability, as well as good properties in terms of solubility, crystal form stability, hygroscopicity and processing adaptability. The patent also provides methods for preparing these new crystal forms and pharmaceutical compositions, cosmetic compositions, functional foods or nutritional agents that contain them. The patent also includes pictures of the polymorphs of pyrroloquinoline quinone disodium salt, showing that they have good solid fluidity, are easy to be filtered and dried, and have high purity, poor hygroscopicity, and good stability.

Problems solved by technology

For example, the crystal form of the pyrroloquinoline quinone sodium salt obtained by the prior art method is unstable and has a high hygroscopicity and a large extent of variation of humidity within the temperature range of storage at normal temperature, and the solid state is not ideal and is not suitable for processing (filtering, drying, tabletting), thus adversely affecting the application and storage of the pyrroloquinoline quinone sodium salt.

Method used

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  • Crystal form of pyrroloquinoline quinone sodium salt and preparation method and use thereof
  • Crystal form of pyrroloquinoline quinone sodium salt and preparation method and use thereof
  • Crystal form of pyrroloquinoline quinone sodium salt and preparation method and use thereof

Examples

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Effect test

example 1

[0095]The pyrroloquinoline quinone trisodium salt solution 100 g (HPLC purity >98%, concentration 0.7%) was heated up to 40° C., stirring was continued for 30 min, the pH was adjusted to 1.0-2.0; filtered to give a clear filtrate, the temperature of the filtrate was decreased to 25° C. with a rate of 10° C. / h and the filtrate was crystallized under stirring at 25° C. for 12 h, the pH was adjusted to 3.0-4.0; stirred, filtered, dried at 25° C. under vacuum to give 0.45 g crystals, purity was 99.1% by HPLC, X-ray powder diffraction pattern showed a new crystal form.

[0096]The X-ray powder diffraction pattern, the infrared absorption spectrum, DSC thermogram and TGA thermogram of the crystal form are detailed in FIGS. 1-4, the crystal form is named as crystal form I of pyrroloquinoline quinone disodium salt in the present invention.

example 2

[0097]The crude pyrroloquinoline quinone 1 g (HPLC purity >98%) was dissolved in 100 mL of water, the temperature was increased to 60° C., stirring was continued for 30 min, dissolved; filtered, the pH was adjusted to 1.0-2.0; filtered to give a clear filtrate, the temperature of the filtrate was decreased to 25° C. with a rate of 10° C. / h and the filtrate was crystallized under stirring at 25° C. for 48 h, the pH was adjusted to 3.0-4.0; stirred, filtered, dried at 25° C. under vacuum to give 0.62 g crystals, purity was 98.8% by HPLC, X-ray powder diffraction pattern showed crystal form I.

example 3

[0098]The crude pyrroloquinoline quinone 1 g (HPLC purity >98%) was dissolved in 100 mL of water, the temperature was increased to 40° C., stirring was continued for 30 min, dissolved; filtered, the temperature was decreased to 15° C., the pH was adjusted to 1.0-2.0; the temperature was increased to 45° C. and the filtrate was crystallized under stirring at 45° C. for 12 h, the pH was adjusted to 3.0-4.0; stirred, filtered, dried at 25° C. under vacuum to give 0.61 g crystals, purity was 99.2% by HPLC, X-ray powder diffraction pattern showed crystal form I.

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Abstract

Provided are crystal forms I, II, III and IV of a pyrroloquinoline quinone sodium salt and a preparation method thereof. Also provided are a pharmaceutical composition, a cosmetic composition, a functional food or a nutritional agent containing the above-mentioned crystal forms. The crystal forms have excellent properties in terms of solubility, crystal stability, hygroscopicity and the like.

Description

TECHNICAL FIELD[0001]The present invention relates to new crystal forms of pyrroloquinoline quinone sodium salt and preparation methods thereof, and the use of the new crystal forms in the fields of medicines, functional foods and cosmetics.TECHNICAL BACKGROUND[0002]Pyrroloquinoline quinone, the chemical name is 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, also known as methaxatin; it has the following structural formula:[0003]Pyrroloquinoline quinone is a small molecule compound found in microorganisms, it is widely distributed in various tissues and organs of the human body and is called the fourteenth vitamin. It is widely used in the fields of medicines, functional foods and cosmetics. For example, pyrroloquinoline quinone can fully improve the body's immune function, in the field of medicines, pyrroloquinoline quinone can be used to prevent and cure liver damage, reduce damage of free radicals to the human body, conditioning a variety of nervous sy...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07D471/04
CPCC07D471/04C07B2200/13A61Q19/00A23L33/10A61K8/4926A61K2800/10A61K31/4745A61P25/28A61P29/00A61P3/02A61P31/00A61P9/10
Inventor YANG, ZHIQINGZHANG, LIANGZHANG, XIANGYANGSHI, ZHENJUANZHAO, MINLUO, HONGYING
Owner ZHEJIANG HISUN PHARMA CO LTD
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