Composition for preventing or treating keloids or hypertrophic scars

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating hypertrophic scars. The present inventors have found that the inhibition of expression of TXNDC5, PRRC1, S100A11, Galectin 1, Filamin A, eIF-5A, Annexin A2, and FABP5 can be a new target for improving and treating hypertrophic scars. In the present invention, TXNDC5-, PRRC1-, S100A11-, Galectin 1-, Filamin A-, eIF-5A-, Annexin A2-, and FABP5-specific siRNAs were constructed to determine the probability of treating the hypertrophic scars. As a result, the knockdown of the protein or a gene encoding the protein induces apoptosis in the hypertrophic scars and reduces collagen expression, which can be very useful in treating wounds.

Description

TECHNICAL FIELD[0001]The present invention relates to a composition for preventing or treating keloids or hypertrophic scars.BACKGROUND ART[0002]When a dermal layer located deep in the skin is damaged due to surgery or trauma, collagen needed to maintain tension of the skin proliferates excessively in the dermal layer so that the collagen emerges from the thin skin even after a wound has healed, leaving a wound-healed scar in the skin, which is referred to “normal scar.” This appears as a result of wound healing, but hypertrophic scars or keloids may appear because fibrous tissues grow abnormally in a compact manner when the skin has a dysfunction in properly regulating and inhibiting a wound healing process. The hypertrophic scars are different from the keloids in that the hypertrophic scars do not extend beyond a wound area and tend to gradually disappear over time, but the keloids grow wider than a damaged area and penetrate into a normal skin over time. There have been various a...

AI Technical Summary

Benefits of technology

[0038]According to the present invention, by identifying a protein which is involved in abnormal collagen formation in a wound area that may cause keloid or hypertrophic scars, the hypertrophic scars can be accurately diagnosed using the corresponding protein and a gene encoding the protein. Also, a material that inhibits the expression and activity of the proteins or genes can be provided, and thus effectively used to alleviate and treat the keloid or hypertrophic scars.

Problems solved by technology

When a dermal layer located deep in the skin is damaged due to surgery or trauma, collagen needed to maintain tension of the skin proliferates excessively in the dermal layer so that the collagen emerges from the thin skin even after a wound has healed, leaving a wound-healed scar in the skin, which is referred to “normal scar.” This appears as a result of wound healing, but hypertrophic scars or keloids may appear because fibrous tissues grow abnormally in a compact manner when the skin has a dysfunction in properly regulating and inhibiting a wound healing process.

There have been various attempts to treat the hypertrophic scars or keloids, including surgical therapy, radiotherapy, steroid therapy, occlusive dressing with silicone gel, laser therapy, and the like, but these methods have limited effects.

It was known that hypertrophic scars or keloids are formed due to the excessive accumulation of collagen when movement of cells is overactivated during a wound healing process, or when the collagen is formed excessively or is not degraded normally as the cells and capillary vessels proliferate abnormally.

There is little information on biomarkers that participate in formation of collagen, which excessively accumulates during the wound healing process, and proliferation of cells.

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