6 results about "C h bond" patented technology

The present invention discloses a biphenyl bridged cyclic peptide compound and a preparation method and application thereof. Phenylalanine or p-hydroxyphenylalanine, which is easily available, is used as the initial raw material. After methylation, protective groups are installed on the carboxyl group and the amino group to obtain two intermediate compounds. The installed 2-methoxyiminoacyl group (methoxyoxime acyl group) is used to guide the transition metal to activate the carbon-hydrogen bond, and the two intermediates are connected in the form of a carbon-carbon bond. Finally, after hydrogenation reduction, lactamization ring closure is performed to obtain the biphenyl bridged cyclic peptide compound. The present invention utilizes the bidentate ligand guiding function of the 2-methoxyiminoacyl group and the instantaneous guiding function of norbornene (NBE) to guide the transition metal to activate the sp at the meta position of the aromatic ring. 2 The carbon-hydrogen bond is formed, and then an arylation reaction occurs to construct a biphenyl structure. The 2-methoxyiminoacyl group is then hydrogenated to form a dipeptide structure, and finally the biphenyl cyclic peptide is constructed by lactamization. The entire route is simple and efficient, and is expected to be further promoted and applied.

The invention relates to the field of synthesis of organic compounds, in particular to a double-C-N axial chiral heterocyclic compound and a preparation method thereof. The double-C-N axial chiral heterocyclic compound is a compound as shown in a formula I. The double-C-N axial chiral heterocyclic compound is prepared by taking quinoline-oriented benzamide as a substrate, taking large-steric-hindrance alkyne of an indole skeleton as a coupling reagent and taking cobalt salt as a catalyst through a cobalt-catalyzed carbon-hydrogen bond asymmetric activation reaction. And the method has the advantages of high yield, excellent enantioselectivity, simple and efficient reaction, mild conditions and avoidance of use of toxic chemical oxidants, and researches in the field of optical properties show that the system has potential application prospects.

The invention discloses a P450 hydroxylase mutant (named as P450AHS) and application of the P450 hydroxylase mutant in biosynthesis of axially chiral allenol compounds, and relates to the technical field of synthesis of the axially chiral allenol compounds. The P450 hydroxylase mutant has a function of biologically catalyzing allene carbon-hydrogen bond hydroxylation to synthesize an axially chiral allene alcohol compound, has high catalytic activity, is environment-friendly, is simple and convenient to operate, and has a wide application prospect.

This invention provides a class of organic light-emitting diode (OLED) host material derivatives and their synthesis methods. Specifically, the host material derivatives have the structure shown in Formula I, and the host material can be derivatized through a high-valent iodine reagent C-H bond functionalization reaction to obtain host material derivatives with different functional group modifications.

The invention relates to compound preparation and belongs to the field of organic synthesis preparation. The invention particularly relates to a carbon-hydrogen bond fluoroalkenylation reaction without metal participation under a mild condition, and is used for preparing a fluoroolefin compound with high stereoselectivity. Fluoroacrylic acid and hydrocarbon are used as raw materials, Eosin Y is used as a catalyst, tert-butyl peroxyacetate is used as an initiator, and the Z-monofluoroolefin compound with the general formula (I) is obtained. The feeding mode of the reaction system is simple and easy to implement, and the reaction system has high synthesis economic value. According to the method, a high-efficiency, green, convenient, economical and practical way for preparing fluoroolefin is provided for carrying out carbon-hydrogen bond direct monofluoroalkenylation reaction under a metal-free condition.

The present invention provides a catalyst for the primary amination reaction of sp<supgt;3< / supgt>-C-H bonds and a method for preparing primary amine compounds, belonging to the technical field of chemical synthesis. The structure of the catalyst is shown in Formula I. The method for preparing primary amine compounds using this catalyst in the present invention has high generality, wide substrate applicability for the reaction, is environmentally friendly, has mild reaction conditions and is not harsh, and the reaction operation is simple, having potential industrial application prospects.