Heat-sensitive gel preparation and preparing method thereof
A technology of heat-sensitive gels and preparations, which is used in pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery, etc., can solve the problems of high total proportion of poloxamer materials, increased material consumption, and high solution viscosity, and achieves Improved heat-sensitive properties, easy cleaning, no greasy feel
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Embodiment 1
[0030] The influence of each component of embodiment 1 on phase transition temperature
[0031] Phase transition temperature measurement method: put 3g of sample in a 10ml test tube, put it in a temperature-controllable water bath, and measure the temperature of the sample with a built-in thermometer in the test tube. From 25°C, every time it rises by 1°C, keep it for 3 minutes, and immediately observe whether the sample is Changes from a flowable liquid to an immobile gel. After the phase transition occurs, take it out and place it at room temperature to observe whether it returns to liquid to judge whether the phase transition is reversible.
[0032] The following samples were observed.
[0033] Experimental method: Poloxamer 407 was prepared into a 25% solution with pH 5.0 phosphate buffer. Using this solution as a solvent, the following 5 samples were prepared for testing.
[0034] 1. Dissolve 0.75g of borneol in 4.0g of ethanol, add 34.4g of the above poloxamer solutio...
Embodiment 2
[0043] Prescription (10 sticks) (g)
[0044] Litsea Cube Seed Oil 0.84
[0045] Borneol 0.75
[0046] Ethanol 4.0
[0047] Poloxamer 407 8.6
[0048] pH5.0 Phosphate buffer 25.81
[0049] According to the prescription, weigh each component, add poloxamer 407 into pH 5.0 phosphate buffer, stir to dissolve. The borneol is dissolved in ethanol, the obtained solution is mixed with the litsea cubeba oil, the obtained mixed solution is added into the poloxamer 407 solution, and the stirring is continued, and the preparation process can be completed at a room temperature of 15-25°C. The resulting mixed solution is a translucent flowable liquid. Each unit preparation is 4g, divided into disposable vaginal injectors, plus outer packaging. Injected into the vagina when used.
[0050] According to the method described in Example 1, the phase transition temperature is 29° C., which is reversible.
Embodiment 3
[0052] Prescription (10 sticks) (g)
[0053] Patchouli Oil 0.84
[0054] Borneol 0.75
[0055] Ethanol 4.0
[0056] Poloxamer 407 8.6
[0057] pH5.0 Phosphate buffer 25.81
[0058] According to the prescription, weigh each component, add poloxamer 407 into pH 5.0 phosphate buffer, stir to dissolve. Dissolving the borneol with ethanol, mixing the obtained solution with patchouli oil, adding the obtained mixed solution into the poloxamer 407 solution, and constantly stirring, and the preparation process can be completed at room temperature. The resulting mixed solution is a translucent flowable liquid. Each unit preparation is 4g, divided into disposable vaginal injectors, plus outer packaging. Injected into the vagina when used.
[0059] According to the method described in Example 1, the phase transition temperature is 29° C., which is reversible.
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