Method for preparation of polyester magnetic composite microsphere capable of being biodegraded

A technology of magnetic composite microspheres and biodegradable polyesters, which is applied in the directions of non-active components of medical preparations, pharmaceutical formulations, etc., can solve the problem of wide particle size distribution, weak magnetic responsiveness and low magnetic content of magnetic polyester composite microspheres. and other problems, to achieve the effect of good biodegradability, good biocompatibility and high magnetic content

Inactive Publication Date: 2008-09-17
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to propose a biodegradable polyester magnetic composite microsphere for the problems of wide particle size distribution, low magnetic content, weak magnetic response and poor stability prepared by the traditional physical embedding method. Preparation method of microspheres

Method used

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  • Method for preparation of polyester magnetic composite microsphere capable of being biodegraded
  • Method for preparation of polyester magnetic composite microsphere capable of being biodegraded

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Lactic acid surface modification Fe 3 o 4 Nanoparticles

[0023] Add 0.5g Fe to the reaction flask 3 o 4 Particles and 40ml of dioxane are ultrasonically dispersed, and 10ml of lactic acid is slowly added dropwise under stirring. After the lactic acid is completely added, stir and react in a water bath at 40°C for 6 hours. After the product is cooled, it is magnetically separated and washed repeatedly with dioxane and ethanol. Vacuum freeze-drying at -50°C for 48 hours to obtain lactic acid surface-modified Fe 3 o 4 Nanoparticles.

Embodiment 2

[0024] Embodiment 2: Lactic acid surface modification Fe 3 o 4 Nanoparticles

[0025] Add 0.8g Fe to the reaction flask 3 o 4 Particles and 60ml tetrahydrofuran, ultrasonically dispersed, slowly add 15ml lactic acid dropwise under stirring state, after the lactic acid is completely added, N 2 Protected, stirred and reacted in a water bath at 50°C for 4h, the product was cooled and then magnetically separated, washed repeatedly with dioxane and ethanol, and vacuum freeze-dried at -50°C for 48h to obtain lactic acid surface-modified Fe 3 o 4 Nanoparticles.

Embodiment 3

[0026] Example 3: Preparation of magnetic polyester composite microspheres by ring-opening polymerization of monomers on the surface of modified particles

[0027] 0.24g surface lactic acid modified Fe prepared in Example 1 3 o 4 The particles were ultrasonically dispersed in 60ml of xylene, 4.1g of lactide monomer and 15mg of stannous octoate catalyst were added, under anhydrous and anaerobic conditions, the reaction was stirred at 125°C for 48h, the product was magnetically separated, and the precipitate was washed repeatedly with xylene and ethanol , and then dialysis with 0.1mol / L HCl to remove uncoated Fe 3 o 4 Particles were finally washed with deionized water until neutral, and vacuum freeze-dried at -50°C for 48 hours to obtain a particle size of 130-320nm, Fe 3 o 4 The magnetic polyester composite microsphere with content of 27% and saturation magnetization of 20.7emu / g.

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Abstract

The invention discloses a magnetic composite micro-ball preparing method of poly-grafted biological decomposable polyester on the nanometer particle surface of lactic modified Fe3O4, which comprises the following steps: heating and stirring lactic acid and hydroxyl group on the Fe3O4 particle surface to dehydrate, bonding lactic acid on the magnetic particle surface, adopting octoic stannate as catalyst under waterless oxygen-less condition, making -O-H on the negative lactic acid of Fe3O4 nanometer particle as trigger agent, triggering loop-typed ester monomer (lactide, glycolide, yimxilong- caprolactone) to open ring and polymerize, forming polyester case on the magnetic particle surface to obtain the product.

Description

technical field [0001] The invention belongs to the technical field of preparation of magnetic polyester composite microspheres, in particular to lactic acid modified Fe 3 o 4 A method for preparing magnetic composite microspheres by polymerizing and grafting biodegradable polyester on the surface of nanoparticles. Background technique [0002] Aliphatic polyester magnetic composite microspheres have many excellent properties of polyester (good biocompatibility, biodegradability, non-toxicity) and magnetic responsiveness of magnetic substances. On the one hand, they can bind enzymes through covalent bonds. , cells and antibodies and other biologically active substances, on the other hand, it can show a strong magnetic response to an external magnetic field, so it can be used as a carrier for enzymes, cells, drugs, etc. and is widely used in biomedicine, cytology and bioengineering. . [0003] However, there are few reports on the preparation of magnetic composite microsph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/48A61K47/52A61K47/59
Inventor 任杰王佐滕新荣
Owner TONGJI UNIV
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